Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) AbkB-brnA/BrnT-BrnA
Location 113596..114184 Replicon plasmid pRIVM_C010761_1
Accession NZ_CP089045
Organism Acinetobacter ursingii strain RIVM_C010761

Toxin (Protein)


Gene name AbkB Uniprot ID -
Locus tag LSO58_RS17030 Protein ID WP_130114512.1
Coordinates 113596..113883 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag LSO58_RS17035 Protein ID WP_130114513.1
Coordinates 113870..114184 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO58_RS17000 (LSO58_16970) 108948..109457 - 510 WP_005005759.1 hypothetical protein -
LSO58_RS17005 (LSO58_16975) 109463..109885 - 423 WP_005005760.1 hypothetical protein -
LSO58_RS17010 (LSO58_16980) 110050..110703 + 654 WP_005005764.1 hypothetical protein -
LSO58_RS17015 (LSO58_16985) 111033..112165 + 1133 WP_223155595.1 IS3-like element ISAba14 family transposase -
LSO58_RS17020 (LSO58_16990) 112292..112711 + 420 WP_263503917.1 AraC family transcriptional regulator -
LSO58_RS17025 (LSO58_16995) 112761..113366 + 606 WP_000447788.1 LysE family translocator -
LSO58_RS17030 (LSO58_17000) 113596..113883 + 288 WP_130114512.1 BrnT family toxin Toxin
LSO58_RS17035 (LSO58_17005) 113870..114184 + 315 WP_130114513.1 BrnA antitoxin family protein Antitoxin
LSO58_RS17040 (LSO58_17010) 114261..114488 - 228 Protein_92 ISNCY family transposase -
LSO58_RS17045 (LSO58_17015) 114529..115239 - 711 Protein_93 IS6-like element IS1006 family transposase -
LSO58_RS17050 (LSO58_17020) 115301..116002 + 702 Protein_94 IS3 family transposase -
LSO58_RS17055 (LSO58_17025) 116192..116556 - 365 Protein_95 copper-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 / aac(3)-IId / mph(E) / msr(E) / sul1 / qacE / catB3 / blaIMP-4 / dfrA19 / blaCARB-2 / aph(3')-Ia - 1..258901 258901
- inside IScluster/Tn blaOXA-58 / aac(3)-IId - 92022..115774 23752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11262.71 Da        Isoelectric Point: 6.0900

>T227558 WP_130114512.1 NZ_CP089045:113596-113883 [Acinetobacter ursingii]
MKQYFEWDEAKNRKNQKKHDVSFETASLVFEDPLRISIQDRHTDGEERWQTIGKVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERDKYEHG

Download         Length: 288 bp

>T227558 NZ_CP122947:c1060258-1059494 [Helicobacter pylori]
ATGGAAACTAAAGAAGAAGATAAAGATAAAAAGCTAGAAGAAATTATTGTATCGCTGTGCAAAGAGGGGGATTTGTCTGG
TCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAGGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCTACAAGGGATAAAGAGCAAGCCTTTATGACGCTCACACAAAACATAAGGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATAAATTTAGAGTGTATCAGATTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATCAGGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAGCAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAATCTATTTTTTGGTTTAATCTGATGGTTACAATCCTATTTGTGATTGGTTTTGTG
GGAGAATTGCATATAATACAAAGATTAGCTTCTAAATATTTTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12254.89 Da        Isoelectric Point: 7.4024

>AT227558 WP_130114513.1 NZ_CP089045:113870-114184 [Acinetobacter ursingii]
MSMVRHSRKELNEKFSDKQDAEIERLLAKGTVPDDHLDLSDMPEITDWSNAVRHNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT227558 NZ_CP122947:c1060685-1060248 [Helicobacter pylori]
ATGGTCAATGCTTTGGAACTAGCAAAATATATTCTTAAGCGTTCAAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATATG
GGCCTGTTGCAAGAGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAATTGGAAACCATCAATTACTCCATAGAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAGTCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References