Detailed information of TA system TA227556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1457864..1458438
• Replicon: chromosome
• Accession: NZ_CP089044
• Organism: Acinetobacter ursingii strain RIVM_C010761

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0M1I0S9
• Locus tag: LSO58_RS06850
• Protein ID: WP_048764206.1
• Coordinates: 1457864..1458052 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LSO58_RS06855
• Protein ID: WP_263503755.1
• Coordinates: 1458055..1458438 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LSO58_RS06830 (LSO58_06810)	1453848..1454561	-	714	WP_263503751.1	hypothetical protein	-
LSO58_RS06835 (LSO58_06815)	1454852..1456393	+	1542	WP_263503752.1	SIR2 family protein	-
LSO58_RS06840 (LSO58_06820)	1456419..1456775	-	357	WP_263503753.1	Arc family DNA-binding protein	-
LSO58_RS06845 (LSO58_06825)	1456979..1457794	+	816	WP_263503754.1	BRO family protein	-
LSO58_RS06850 (LSO58_06830)	1457864..1458052	+	189	WP_048764206.1	type II toxin-antitoxin system HicA family toxin	Toxin
LSO58_RS06855 (LSO58_06835)	1458055..1458438	+	384	WP_263503755.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LSO58_RS06860	1458613..1458741	+	129	WP_263503756.1	hypothetical protein	-
LSO58_RS06865 (LSO58_06840)	1459159..1461903	+	2745	WP_263503757.1	phage tail tape measure protein	-
LSO58_RS06870 (LSO58_06845)	1461903..1462364	+	462	WP_263503758.1	phage tail protein	-
LSO58_RS06875 (LSO58_06850)	1462364..1462579	+	216	WP_151829815.1	tail protein X	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1418051..1518480	100429

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7288.43 Da
• Isoelectric Point: 10.5461

>T227556 WP_048764206.1 NZ_CP089044:1457864-1458052 [Acinetobacter ursingii]
MNSKEIIKRLEQEGWIKVGGKGDHEKFKHPEKSGHVVVPHPRKDMPIGTLRNIYKQAGWEWR

Nucleotide

• Length: 189 bp

>T227556 NZ_CP122946:c1079136-1078870 [Helicobacter pylori]
ATGCTGAAAATTAAGCACCATATCCTTTACAAAAAAGATTTTAAAAAACTTGTTAAAAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCGCTACCCCCACAATTTCAAGATCATGCCTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCCGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTAATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14352.21 Da
• Isoelectric Point: 4.4225

>AT227556 WP_263503755.1 NZ_CP089044:1458055-1458438 [Acinetobacter ursingii]
MLYPVYVHKDQDSAYGLTFPDFEGCFSAADDMQDIQRMAQEAVEVHFDGEDLPLPEPSSPEQWIGDDRFEGGYWLLVDID
LSKISSKSVRINISMPESLVKRIDAMAKKQHLSRSAFLAKSAEMALH

Nucleotide

• Length: 384 bp

>AT227556 NZ_CP122946:c1079494-1079123 [Helicobacter pylori]
ATGCCTAACTCTTCTGCCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAATCTAATCAATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGCGAAAACTTAGAAACTATTGAAGA
CTTTTCTGCATGGGCAAATGAAATAAAAAAGGAAGTGAATGCTGAAAATTAA

Structures

Toxin

• AlphaFold DB: A0A0M1I0S9