Detailed information of TA system TA227552

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 522418..523051
• Replicon: chromosome
• Accession: NZ_CP089038
• Organism: Acinetobacter ursingii strain RIVM_C011601

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LSO59_RS02585
• Protein ID: WP_010588898.1
• Coordinates: 522668..523051 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2N6VED5
• Locus tag: LSO59_RS02580
• Protein ID: WP_004985373.1
• Coordinates: 522418..522675 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LSO59_RS02560 (LSO59_02555)	517916..518923	+	1008	WP_004924164.1	DNA-directed RNA polymerase subunit alpha	-
LSO59_RS02565 (LSO59_02560)	518942..519319	+	378	WP_004924167.1	50S ribosomal protein L17	-
LSO59_RS02570 (LSO59_02565)	519487..520983	+	1497	WP_004985369.1	NAD(P)/FAD-dependent oxidoreductase	-
LSO59_RS02575 (LSO59_02570)	521057..522229	-	1173	WP_004985371.1	acyl-CoA dehydrogenase family protein	-
LSO59_RS02580 (LSO59_02575)	522418..522675	+	258	WP_004985373.1	succinate dehydrogenase assembly factor 2	Antitoxin
LSO59_RS02585 (LSO59_02580)	522668..523051	+	384	WP_010588898.1	hypothetical protein	Toxin
LSO59_RS02590 (LSO59_02585)	523594..524718	+	1125	WP_004985378.1	hypothetical protein	-
LSO59_RS02595 (LSO59_02590)	524831..525424	+	594	WP_004985380.1	rhombosortase	-
LSO59_RS02600 (LSO59_02595)	525581..527779	+	2199	WP_010588897.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 15506.62 Da
• Isoelectric Point: 10.8548

>T227552 WP_010588898.1 NZ_CP089038:522668-523051 [Acinetobacter ursingii]
MVNHQFQLKRSLLALLFQLGMLLLIGIIWFQLFPFYIFLIAIFLAIIAYLAFLRRSKMRSLAYLDQDLWSIQWRNHSKIE
HVQLYRVIDHHIYIVLYFKQNRNSQIIWRDQVSLNQWKQLKVMAKLV

Nucleotide

• Length: 384 bp

>T227552 NZ_CP122941:c21681-21301 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGACGCGAATATAAGCCGCTACGGCGGCTTGCCGGGAATGTC
AGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGCGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10137.60 Da
• Isoelectric Point: 4.7414

>AT227552 WP_004985373.1 NZ_CP089038:522418-522675 [Acinetobacter ursingii]
MSEELTLEERKVIYRARRGLKEIDVYFDPYVRNHYLSAEPAEKALFAELVDQEDPDLLDWFMEVSEPPKPELKTFILKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT227552 NZ_CP122941:c21902-21681 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Antitoxin

• AlphaFold DB: A0A2N6VED5