Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3548258..3548736 Replicon chromosome
Accession NZ_CP089036
Organism Escherichia coli O157:H7 strain 7386WT

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag CO544_RS18465 Protein ID WP_001303876.1
Coordinates 3548449..3548736 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag CO544_RS18460 Protein ID WP_000536233.1
Coordinates 3548258..3548449 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO544_RS18425 (3543656) 3543656..3544426 - 771 WP_000450992.1 DUF1627 domain-containing protein -
CO544_RS18430 (3544448) 3544448..3545194 - 747 WP_000788745.1 ATP-binding protein -
CO544_RS18435 (3545201) 3545201..3546298 - 1098 WP_001475117.1 hypothetical protein -
CO544_RS18440 (3546377) 3546377..3546832 + 456 WP_000273724.1 hypothetical protein -
CO544_RS18445 (3547039) 3547039..3547464 - 426 WP_000693855.1 toxin YdaT family protein -
CO544_RS18450 (3547448) 3547448..3547720 - 273 WP_000887453.1 YdaS family helix-turn-helix protein -
CO544_RS18455 (3547829) 3547829..3548230 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
CO544_RS18460 (3548258) 3548258..3548449 + 192 WP_000536233.1 hypothetical protein Antitoxin
CO544_RS18465 (3548449) 3548449..3548736 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CO544_RS18470 (3549014) 3549014..3549169 + 156 WP_000379575.1 DUF1391 family protein -
CO544_RS27910 (3549171) 3549171..3549299 + 129 WP_000344963.1 protein YdfB -
CO544_RS18475 (3549311) 3549311..3549700 + 390 WP_000394511.1 hypothetical protein -
CO544_RS18480 (3549887) 3549887..3550072 - 186 WP_001133046.1 hypothetical protein -
CO544_RS18485 (3550646) 3550646..3550834 + 189 WP_000413705.1 cell division inhibition protein DicB -
CO544_RS18490 (3550831) 3550831..3551022 + 192 WP_001098307.1 DUF1482 family protein -
CO544_RS18495 (3551116) 3551116..3553587 + 2472 WP_231824914.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T227542 WP_001303876.1 NZ_CP089036:3548449-3548736 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T227542 NZ_CP122938:c3015663-3015286 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATAACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT227542 WP_000536233.1 NZ_CP089036:3548258-3548449 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT227542 NZ_CP122938:c3016120-3015752 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCAAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References