Detailed information of TA system TA022753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 1024639..1025393
• Replicon: chromosome
• Accession: NC_010513
• Organism: Xylella fastidiosa M12

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: XFASM12_RS04405
• Protein ID: WP_021358673.1
• Coordinates: 1024639..1025118 (-)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: XFASM12_RS04410
• Protein ID: WP_004085396.1
• Coordinates: 1025121..1025393 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFASM12_RS04395	1021492..1022298	+	807	WP_012337796.1	oxidoreductase	-
XFASM12_RS04400	1022438..1024303	+	1866	WP_012337797.1	toprim domain-containing protein	-
XFASM12_RS04405	1024639..1025118	-	480	WP_021358673.1	GNAT family N-acetyltransferase	Toxin
XFASM12_RS04410	1025121..1025393	-	273	WP_004085396.1	DUF1778 domain-containing protein	Antitoxin
XFASM12_RS04415	1025745..1026650	-	906	WP_004085395.1	AEC family transporter	-
XFASM12_RS04420	1026766..1027384	+	619	Protein_857	IS607 family transposase	-
XFASM12_RS04425	1027579..1029645	+	2067	WP_004085393.1	glycosyl hydrolase family 3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (33-146)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-85)

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 17645.42 Da
• Isoelectric Point: 9.9283

>T22753 WP_021358673.1 NC_010513:c1025118-1024639 [Xylella fastidiosa M12]
MQISTPHSLTAAHRLDEFNCGEPSLDDWLKRRALTNHLNGASRTFVVIDANQYVLGYYALAAGAVAHQEATRAIRRNMPD
PVPVMVLGRLAVDTRAQGIKLGAALLKDTVTRVQSIAENAGVRALVVHALNERAKQFYEYYGFRASPMHLMTLMLPIKF

Nucleotide

• Length: 480 bp

>T22753 NC_010513:c1025118-1024639 [Xylella fastidiosa M12]
ATGCAGATTTCGACACCTCATTCACTCACGGCAGCGCATCGACTTGATGAATTCAATTGCGGTGAGCCATCGCTGGATGA
TTGGCTTAAACGACGCGCACTGACCAACCATTTAAACGGGGCCAGCCGGACCTTCGTGGTTATCGATGCCAACCAATACG
TGCTTGGGTACTACGCTTTGGCAGCCGGGGCTGTAGCGCATCAAGAGGCCACCCGTGCTATCCGACGTAACATGCCTGAT
CCAGTGCCGGTCATGGTGCTCGGAAGGCTGGCTGTGGATACTCGTGCTCAAGGCATCAAACTCGGTGCGGCCTTGCTTAA
AGATACGGTAACTCGTGTGCAGTCCATTGCAGAGAACGCCGGCGTCAGGGCATTGGTAGTCCATGCGTTGAACGAGCGCG
CAAAGCAATTCTACGAGTACTATGGTTTTCGAGCGTCACCAATGCACCTGATGACCTTGATGCTTCCGATTAAATTCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10264.77 Da
• Isoelectric Point: 5.0488

>AT22753 WP_004085396.1 NC_010513:c1025393-1025121 [Xylella fastidiosa M12]
MRDASINLRAMPEQRDLIDQAANLLGKNRSDFMLEAACERAKAIILDQVFFNLDEERFRQFTVLLNAPQDTNPGLNRLMA
IKAPWSISNT

Nucleotide

• Length: 273 bp

>AT22753 NC_010513:c1025393-1025121 [Xylella fastidiosa M12]
ATGCGCGACGCTTCCATCAACTTACGTGCCATGCCTGAGCAGCGCGACTTGATTGACCAGGCTGCTAATCTATTAGGCAA
GAATCGCTCAGACTTCATGCTAGAAGCTGCGTGCGAGCGTGCGAAAGCAATTATCCTGGATCAAGTCTTTTTCAATCTGG
ACGAAGAGAGGTTCCGGCAATTCACTGTGTTGCTTAATGCGCCACAAGACACCAATCCAGGCCTTAATCGCCTGATGGCA
ATTAAGGCTCCGTGGAGCATCAGCAATACGTGA