Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 472331..472917 Replicon chromosome
Accession NC_010513
Organism Xylella fastidiosa M12

Toxin (Protein)


Gene name hicA Uniprot ID Q87BV5
Locus tag XFASM12_RS02030 Protein ID WP_004089517.1
Coordinates 472663..472917 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2I6C9
Locus tag XFASM12_RS02025 Protein ID WP_004085025.1
Coordinates 472331..472666 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFASM12_RS01995 469105..469680 - 576 WP_012337655.1 terminase small subunit -
XFASM12_RS02000 469811..470035 - 225 WP_012337656.1 hypothetical protein -
XFASM12_RS02005 470037..470498 - 462 WP_012337657.1 hypothetical protein -
XFASM12_RS02010 470488..470817 - 330 WP_012337658.1 phage holin family protein -
XFASM12_RS02015 470810..471310 - 501 WP_012337659.1 lysozyme -
XFASM12_RS02020 471410..472141 - 732 WP_012337660.1 site-specific DNA-methyltransferase -
XFASM12_RS02025 472331..472666 - 336 WP_004085025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
XFASM12_RS02030 472663..472917 - 255 WP_004089517.1 type II toxin-antitoxin system HicA family toxin Toxin
XFASM12_RS02035 472970..473692 - 723 WP_012337661.1 hypothetical protein -
XFASM12_RS12470 473635..473982 - 348 WP_162010044.1 hypothetical protein -
XFASM12_RS02040 474230..475438 + 1209 Protein_375 DNA polymerase -
XFASM12_RS02045 475435..475713 + 279 WP_012337663.1 VRR-NUC domain-containing protein -
XFASM12_RS02050 475715..476020 - 306 WP_012337664.1 hypothetical protein -
XFASM12_RS02055 476105..477523 + 1419 WP_012337665.1 DEAD/DEAH box helicase -
XFASM12_RS02060 477520..477765 + 246 WP_012337666.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 446909..481283 34374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9639.14 Da        Isoelectric Point: 11.2766

>T22752 WP_004089517.1 NC_010513:c472917-472663 [Xylella fastidiosa M12]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T22752 NC_010513:c472917-472663 [Xylella fastidiosa M12]
ATGAAGCGTAAGCACGCTAAAACTCTCAGCGCTATATACACACGCCCTGTTTCGGCCAACATTCAATGGCGCGATATTGA
AGCGCTGTTCGTGGAGCTTGGAGCGAAAGTAGAAGAACGTGAAGGTTCTCGTATGTTGGTGCGGCTGTTCGGTGAACGTC
GGATATTCCACCGGCCCCACCCTTCGCCTAACACTGACAAGGGTGCTGTTGAATCAATCCGAGCTTGGTTGAAATCGAAC
GGAGTTACACCATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12324.07 Da        Isoelectric Point: 5.6556

>AT22752 WP_004085025.1 NC_010513:c472666-472331 [Xylella fastidiosa M12]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Download         Length: 336 bp

>AT22752 NC_010513:c472666-472331 [Xylella fastidiosa M12]
ATGAAGAACATCATGACTATTGAGAGCTTTAAAGCCATCATTACCTATGATCCGGAGATCGACATGTTTCGCGGTGAATT
TGTGGGTATCAATGGTGGTGCTGATTTCTATGCAAAAGACCTTAAGGGTCTTCGTCGAGAAGGAGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCAAAGAAGACAGCGTGGAACCACGTAAATGCTACTCAGGGAAGTTCAATGCAAGGATTTCTCCT
GAACTGCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGCATCAGTTTGAACCAATTTGTAGAACAAGCGATTCAGCA
TGAAGTCCACACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87BV5

Antitoxin

Source ID Structure
AlphaFold DB A0A060HAK5

References