Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3688030..3688508 Replicon chromosome
Accession NZ_CP089034
Organism Escherichia coli O157:H7 strain 6535NalR

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag LSI70_RS19300 Protein ID WP_001303876.1
Coordinates 3688221..3688508 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag LSI70_RS19295 Protein ID WP_000536233.1
Coordinates 3688030..3688221 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSI70_RS19260 (3683434) 3683434..3684204 - 771 WP_000450992.1 DUF1627 domain-containing protein -
LSI70_RS19265 (3684226) 3684226..3684972 - 747 WP_000788751.1 ATP-binding protein -
LSI70_RS19270 (3684979) 3684979..3686070 - 1092 WP_001205823.1 hypothetical protein -
LSI70_RS19275 (3686149) 3686149..3686604 + 456 WP_000273724.1 hypothetical protein -
LSI70_RS19280 (3686811) 3686811..3687236 - 426 WP_000693855.1 toxin YdaT family protein -
LSI70_RS19285 (3687220) 3687220..3687492 - 273 WP_000887453.1 YdaS family helix-turn-helix protein -
LSI70_RS19290 (3687601) 3687601..3688002 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
LSI70_RS19295 (3688030) 3688030..3688221 + 192 WP_000536233.1 hypothetical protein Antitoxin
LSI70_RS19300 (3688221) 3688221..3688508 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LSI70_RS19305 (3688786) 3688786..3688941 + 156 WP_000379575.1 DUF1391 family protein -
LSI70_RS29015 (3688943) 3688943..3689071 + 129 WP_000344963.1 protein YdfB -
LSI70_RS19310 (3689083) 3689083..3689472 + 390 WP_000394511.1 hypothetical protein -
LSI70_RS19315 (3689659) 3689659..3689844 - 186 WP_001133046.1 hypothetical protein -
LSI70_RS19320 (3690418) 3690418..3690606 + 189 WP_000413705.1 cell division inhibition protein DicB -
LSI70_RS19325 (3690603) 3690603..3690794 + 192 WP_001098307.1 DUF1482 family protein -
LSI70_RS19330 (3690888) 3690888..3693359 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T227508 WP_001303876.1 NZ_CP089034:3688221-3688508 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T227508 NZ_CP122929:c606153-605689 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT227508 WP_000536233.1 NZ_CP089034:3688030-3688221 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT227508 NZ_CP122929:c606488-606153 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References