Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 183526..184163 Replicon chromosome
Accession NC_010508
Organism Burkholderia cenocepacia MC0-3

Toxin (Protein)


Gene name vapC Uniprot ID B1JSY9
Locus tag BCENMC03_RS00805 Protein ID WP_012327631.1
Coordinates 183762..184163 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1JSY8
Locus tag BCENMC03_RS00800 Protein ID WP_012327630.1
Coordinates 183526..183762 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCENMC03_RS00785 179025..180041 + 1017 WP_012327627.1 helix-turn-helix domain-containing protein -
BCENMC03_RS00790 180391..181485 - 1095 WP_012327628.1 hypothetical protein -
BCENMC03_RS00795 181482..183185 - 1704 WP_012327629.1 thiamine pyrophosphate-binding protein -
BCENMC03_RS00800 183526..183762 + 237 WP_012327630.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BCENMC03_RS00805 183762..184163 + 402 WP_012327631.1 type II toxin-antitoxin system VapC family toxin Toxin
BCENMC03_RS00810 184231..185619 - 1389 WP_012327632.1 L-serine ammonia-lyase -
BCENMC03_RS00815 185650..186792 - 1143 WP_012327633.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14976.09 Da        Isoelectric Point: 5.6577

>T22746 WP_012327631.1 NC_010508:183762-184163 [Burkholderia cenocepacia MC0-3]
MPRFMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTACTSPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFASYPGVRLENWLND

Download         Length: 402 bp

>T22746 NC_010508:183762-184163 [Burkholderia cenocepacia MC0-3]
ATGCCGCGCTTCATGCTCGACACCAACATGTGCATCTATTTGATGAAAAATCAGCCGGAGCAGGTCGCGAGACGGTTTGC
GCAGTGCTACACGGGCGACGTCGTCATGTCGGCGATCACCTATGCGGAGCTCGAGTACGGCGTGACCGCATGCACGAGCC
CCGCCCGGGAGCGCCGCCATCTCGCCGCATTGATCGAGGATATTCCCGTCGCGCCTTTCGACGCCGCGGCAGCCCAAGCG
TATGGCCCGGTGCGCGACGCAACCCGCGAGCGGAAGAAGGATCACCTCGACAAATTGATCGCCGCGCATGCGGTGTCGCT
CGATGTCGTCCTGGTGACCAACAACGAGCGGGATTTCGCGAGTTATCCGGGCGTGAGACTTGAGAACTGGTTGAACGACT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9084.24 Da        Isoelectric Point: 5.7316

>AT22746 WP_012327630.1 NC_010508:183526-183762 [Burkholderia cenocepacia MC0-3]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLEKFAKFGPDFMTEGRGDHEQAEREGL

Download         Length: 237 bp

>AT22746 NC_010508:183526-183762 [Burkholderia cenocepacia MC0-3]
ATGCATACCACGAGGGTATTCAGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCGGACCTTGCCTATGAGCGCAGCGA
TATCGAACTGGAAATCGAGCGCGTCGGTGACGAAATCCGCATTCGGCCGATGCGGCGGCCTTTGACTCAGGTACTGGAGA
AGTTCGCGAAATTCGGGCCTGACTTCATGACAGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1JSY9

Antitoxin

Source ID Structure
AlphaFold DB A0A228I1F0

References