Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 3006605..3007076 | Replicon | chromosome |
| Accession | NZ_CP089031 | ||
| Organism | Escherichia coli strain 7386Nal | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | CO543_RS15520 | Protein ID | WP_001303511.1 |
| Coordinates | 3006798..3007076 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | CO543_RS15515 | Protein ID | WP_001302048.1 |
| Coordinates | 3006605..3006796 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CO543_RS15475 (3001812) | 3001812..3002396 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| CO543_RS15480 (3002453) | 3002453..3002848 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| CO543_RS15485 (3002864) | 3002864..3003633 | - | 770 | Protein_3042 | DUF1627 domain-containing protein | - |
| CO543_RS15490 (3003659) | 3003659..3004399 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| CO543_RS15495 (3004406) | 3004406..3005368 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| CO543_RS15500 (3005391) | 3005391..3005816 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| CO543_RS15505 (3005813) | 3005813..3006115 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| CO543_RS15510 (3006213) | 3006213..3006584 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| CO543_RS15515 (3006605) | 3006605..3006796 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| CO543_RS15520 (3006798) | 3006798..3007076 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CO543_RS15525 (3007429) | 3007429..3007728 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| CO543_RS15530 (3007800) | 3007800..3008018 | + | 219 | WP_001171930.1 | protein YdfC | - |
| CO543_RS15535 (3008587) | 3008587..3008775 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| CO543_RS15540 (3008772) | 3008772..3008963 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| CO543_RS15545 (3009056) | 3009056..3010141 | + | 1086 | Protein_3054 | exonuclease | - |
| CO543_RS15550 (3010192) | 3010192..3011405 | + | 1214 | WP_162829202.1 | IS3-like element IS1203 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2967833..3016676 | 48843 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T227441 WP_001303511.1 NZ_CP089031:3006798-3007076 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T227441 NZ_CP122876:707379-707693 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT227441 WP_001302048.1 NZ_CP089031:3006605-3006796 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT227441 NZ_CP122876:707690-708106 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|