Detailed information of TA system TA022743

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3007429..3008348
• Replicon: chromosome
• Accession: NC_010506
• Organism: Shewanella woodyi ATCC 51908

Toxin (Protein)

• Gene name: -
• Uniprot ID: B1KG32
• Locus tag: SWOO_RS12600
• Protein ID: WP_012325081.1
• Coordinates: 3007878..3008348 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: B1KG31
• Locus tag: SWOO_RS12595
• Protein ID: WP_012325080.1
• Coordinates: 3007429..3007881 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SWOO_RS12575	3002747..3003631	-	885	WP_012325076.1	peptidoglycan-binding protein	-
SWOO_RS12580	3003949..3004599	-	651	WP_012325077.1	protein disulfide-isomerase	-
SWOO_RS12585	3004795..3005442	-	648	WP_012325078.1	LysE family translocator	-
SWOO_RS12590	3005965..3007200	+	1236	WP_012325079.1	DUF3103 family protein	-
SWOO_RS12595	3007429..3007881	+	453	WP_012325080.1	DUF2384 domain-containing protein	Antitoxin
SWOO_RS12600	3007878..3008348	+	471	WP_012325081.1	RES family NAD+ phosphorylase	Toxin
SWOO_RS12605	3008716..3011166	+	2451	WP_012325082.1	ATP-binding protein	-
SWOO_RS12610	3011253..3012173	-	921	WP_012325083.1	manganese-dependent inorganic pyrophosphatase	-
SWOO_RS12615	3012365..3012793	+	429	WP_012325084.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (5-136)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (97-147)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17514.75 Da
• Isoelectric Point: 4.4313

>T22743 WP_012325081.1 NC_010506:3007878-3008348 [Shewanella woodyi ATCC 51908]
VITGYRIVKKKWASNAFDGEGARLYGGRWNSRGQSCVYLAGSESLAILEVLVHLENAQQINQYALFSVTLSEEDILLLET
QALPENWQEDPAPSETAELGDEWLCSQSSLALCVPSSIVARENNYLLNINHPHFHQLLSSMVELEFSMDSRLLSRM

Nucleotide

• Length: 471 bp

>T22743 NC_010506:3007878-3008348 [Shewanella woodyi ATCC 51908]
GTGATAACCGGCTACCGGATCGTTAAAAAAAAATGGGCAAGCAATGCCTTTGACGGTGAAGGAGCTAGGCTTTATGGCGG
ACGCTGGAATAGCCGCGGCCAATCCTGTGTGTACCTAGCAGGCTCTGAATCTCTGGCGATTCTGGAAGTATTAGTCCACC
TGGAAAATGCCCAACAAATAAATCAATATGCTCTGTTTTCTGTCACCTTAAGCGAGGAGGATATCCTCTTACTCGAAACT
CAGGCTCTACCGGAGAACTGGCAGGAAGACCCTGCACCATCTGAAACCGCAGAACTAGGAGATGAGTGGCTTTGTAGCCA
AAGCAGTCTCGCGCTCTGTGTCCCTTCCAGTATCGTAGCGAGAGAGAATAACTATCTGCTAAATATCAACCACCCTCACT
TCCATCAGTTATTAAGCAGTATGGTTGAACTAGAGTTCTCTATGGACAGCCGATTACTCTCTAGAATGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16434.83 Da
• Isoelectric Point: 10.1238

>AT22743 WP_012325080.1 NC_010506:3007429-3007881 [Shewanella woodyi ATCC 51908]
MTTMNVFTPTSSAKKVMSFWQLVGVPARGASLYTALHNGLPFEVYAKLAKVSGLEKSELANATVIASATLQRRAKAGKFN
KDESDRLYRFAEVYKSALDLFEGNNHDASNWLKSPVRGLGNKRPIEMLSTSAETEAVLNLIGRLEHGVFA

Nucleotide

• Length: 453 bp

>AT22743 NC_010506:3007429-3007881 [Shewanella woodyi ATCC 51908]
ATGACAACAATGAATGTGTTTACCCCTACCAGCTCAGCAAAAAAGGTGATGAGTTTCTGGCAATTAGTCGGGGTTCCAGC
CCGCGGCGCCAGTTTATACACAGCTTTGCACAATGGGCTTCCTTTTGAAGTTTACGCTAAGCTGGCTAAAGTATCTGGAT
TGGAAAAGTCTGAACTCGCTAATGCCACAGTTATCGCCAGCGCAACACTGCAGCGTCGGGCTAAAGCGGGAAAATTCAAT
AAAGATGAGAGCGATCGTCTATACCGATTTGCTGAAGTTTATAAATCCGCTTTGGATCTATTTGAAGGCAATAATCATGA
TGCCTCCAACTGGCTTAAAAGTCCGGTACGTGGTCTCGGTAACAAACGTCCTATTGAGATGCTGTCTACCTCTGCAGAAA
CTGAAGCGGTATTAAACCTAATAGGCCGATTAGAACACGGTGTATTTGCGTGA

Structures

Toxin

• AlphaFold DB: B1KG32

Antitoxin

• AlphaFold DB: B1KG31