Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 103901..104426 Replicon plasmid p49210-107.8
Accession NZ_CP089028
Organism Klebsiella pneumoniae strain 49210

Toxin (Protein)


Gene name ccdB Uniprot ID J5VBT8
Locus tag LRY78_RS27680 Protein ID WP_004197633.1
Coordinates 104121..104426 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag LRY78_RS27675 Protein ID WP_001568025.1
Coordinates 103901..104119 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRY78_RS27630 (LRY78_27620) 99193..99516 + 324 WP_021312689.1 hypothetical protein -
LRY78_RS27635 (LRY78_27625) 99757..100533 + 777 WP_060617172.1 DUF2971 domain-containing protein -
LRY78_RS27640 (LRY78_27630) 100669..100923 - 255 WP_065810046.1 hypothetical protein -
LRY78_RS27645 (LRY78_27635) 100999..101256 - 258 WP_047665813.1 hypothetical protein -
LRY78_RS27650 (LRY78_27640) 101305..101508 - 204 WP_004152106.1 HHA domain-containing protein -
LRY78_RS27655 (LRY78_27645) 101542..101910 - 369 WP_064148000.1 hypothetical protein -
LRY78_RS27660 (LRY78_27650) 101954..102448 - 495 WP_124043240.1 DNA-binding protein -
LRY78_RS27665 (LRY78_27655) 102479..103045 - 567 WP_124043238.1 hypothetical protein -
LRY78_RS27670 (LRY78_27660) 103042..103305 - 264 WP_047665809.1 hypothetical protein -
LRY78_RS27675 (LRY78_27665) 103901..104119 + 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LRY78_RS27680 (LRY78_27670) 104121..104426 + 306 WP_004197633.1 type II toxin-antitoxin system toxin CcdB Toxin
LRY78_RS27685 (LRY78_27675) 104595..104996 + 402 WP_073558206.1 hypothetical protein -
LRY78_RS27690 (LRY78_27680) 105023..105346 + 324 WP_004197641.1 hypothetical protein -
LRY78_RS27695 (LRY78_27685) 105343..106359 + 1017 WP_046664221.1 hypothetical protein -
LRY78_RS27700 (LRY78_27690) 106557..107342 + 786 WP_046664219.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(E) / msr(E) / armA / sul1 / qacE / aac(6')-Ib-cr - 1..107790 107790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11585.27 Da        Isoelectric Point: 6.4661

>T227422 WP_004197633.1 NZ_CP089028:104121-104426 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T227422 NZ_CP122872:c664495-664031 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT227422 WP_001568025.1 NZ_CP089028:103901-104119 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT227422 NZ_CP122872:c664830-664495 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MCG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References