Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4913893..4914409 Replicon chromosome
Accession NZ_CP089024
Organism Klebsiella pneumoniae strain 49210

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LRY78_RS23985 Protein ID WP_004178374.1
Coordinates 4913893..4914177 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LRY78_RS23990 Protein ID WP_002886901.1
Coordinates 4914167..4914409 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRY78_RS23960 (4909289) 4909289..4909552 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LRY78_RS23965 (4909682) 4909682..4909855 + 174 WP_041169004.1 hypothetical protein -
LRY78_RS23970 (4909858) 4909858..4910601 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LRY78_RS23975 (4910958) 4910958..4913096 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LRY78_RS23980 (4913425) 4913425..4913889 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRY78_RS23985 (4913893) 4913893..4914177 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRY78_RS23990 (4914167) 4914167..4914409 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRY78_RS23995 (4914487) 4914487..4916397 - 1911 WP_012737231.1 PRD domain-containing protein -
LRY78_RS24000 (4916420) 4916420..4917574 - 1155 WP_012737230.1 lactonase family protein -
LRY78_RS24005 (4917641) 4917641..4918381 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T227420 WP_004178374.1 NZ_CP089024:c4914177-4913893 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T227420 NZ_CP122871:c57549-57262 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGGCTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGTGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGCGAAAGAATGAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT227420 WP_002886901.1 NZ_CP089024:c4914409-4914167 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT227420 NZ_CP122871:c57797-57546 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAACCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TTGATGCCCTAGACGATCAGGAGTTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGATCTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References