Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4157447..4158066 Replicon chromosome
Accession NZ_CP089024
Organism Klebsiella pneumoniae strain 49210

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LRY78_RS20415 Protein ID WP_002892050.1
Coordinates 4157848..4158066 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LRY78_RS20410 Protein ID WP_002892066.1
Coordinates 4157447..4157821 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRY78_RS20400 (4152599) 4152599..4153792 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LRY78_RS20405 (4153815) 4153815..4156961 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LRY78_RS20410 (4157447) 4157447..4157821 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LRY78_RS20415 (4157848) 4157848..4158066 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LRY78_RS20420 (4158225) 4158225..4158791 + 567 WP_002892030.1 maltose O-acetyltransferase -
LRY78_RS20425 (4158763) 4158763..4158903 - 141 WP_004147370.1 hypothetical protein -
LRY78_RS20430 (4158924) 4158924..4159394 + 471 WP_002892026.1 YlaC family protein -
LRY78_RS20435 (4159369) 4159369..4160820 - 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
LRY78_RS20440 (4160921) 4160921..4161619 + 699 WP_002892021.1 GNAT family protein -
LRY78_RS20445 (4161616) 4161616..4161756 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LRY78_RS20450 (4161756) 4161756..4162019 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T227418 WP_002892050.1 NZ_CP089024:4157848-4158066 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T227418 NZ_CP122870:c21245-20985 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCTGATCTTGTTTTTCATGAGGAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT227418 WP_002892066.1 NZ_CP089024:4157447-4157821 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT227418 NZ_CP122870:c20995-20744 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCTGAAAT
ATTCAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References