Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4893098..4893933 Replicon chromosome
Accession NC_010498
Organism Escherichia coli SMS-3-5

Toxin (Protein)


Gene name yeeV Uniprot ID B1LDL9
Locus tag ECSMS35_RS24145 Protein ID WP_001094444.1
Coordinates 4893556..4893933 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag ECSMS35_RS24140 Protein ID WP_001285607.1
Coordinates 4893098..4893466 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECSMS35_RS24110 4888990..4889670 + 681 WP_001282919.1 WYL domain-containing protein -
ECSMS35_RS24115 4889818..4890495 + 678 WP_001097301.1 hypothetical protein -
ECSMS35_RS27675 4890525..4890734 + 210 WP_032150870.1 DUF905 family protein -
ECSMS35_RS24120 4890824..4891642 + 819 WP_001175175.1 DUF945 domain-containing protein -
ECSMS35_RS24125 4891734..4892219 + 486 WP_000213722.1 antirestriction protein -
ECSMS35_RS24130 4892234..4892710 + 477 WP_001384029.1 RadC family protein -
ECSMS35_RS24135 4892797..4893018 + 222 WP_000692350.1 DUF987 domain-containing protein -
ECSMS35_RS24140 4893098..4893466 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECSMS35_RS24145 4893556..4893933 + 378 WP_001094444.1 TA system toxin CbtA family protein Toxin
ECSMS35_RS24150 4893930..4894418 + 489 WP_000761685.1 hypothetical protein -
ECSMS35_RS24155 4894438..4894635 + 198 WP_001327226.1 DUF957 domain-containing protein -
ECSMS35_RS29555 4894720..4894866 + 147 WP_001290178.1 hypothetical protein -
ECSMS35_RS24160 4895330..4896157 + 828 Protein_4547 integrase arm-type DNA-binding domain-containing protein -
ECSMS35_RS25885 4896232..4896431 + 200 Protein_4548 transposase -
ECSMS35_RS24170 4896629..4897522 - 894 WP_000291809.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14087.02 Da        Isoelectric Point: 7.3523

>T22741 WP_001094444.1 NC_010498:4893556-4893933 [Escherichia coli SMS-3-5]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T22741 NC_010498:4893556-4893933 [Escherichia coli SMS-3-5]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT22741 WP_001285607.1 NC_010498:4893098-4893466 [Escherichia coli SMS-3-5]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT22741 NC_010498:4893098-4893466 [Escherichia coli SMS-3-5]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1LDL9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References