Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4931241..4931757 Replicon chromosome
Accession NZ_CP089021
Organism Klebsiella pneumoniae strain 53370

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LRZ76_RS23690 Protein ID WP_004178374.1
Coordinates 4931241..4931525 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LRZ76_RS23695 Protein ID WP_002886901.1
Coordinates 4931515..4931757 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ76_RS23665 (4926637) 4926637..4926900 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LRZ76_RS23670 (4927030) 4927030..4927203 + 174 WP_041169004.1 hypothetical protein -
LRZ76_RS23675 (4927206) 4927206..4927949 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LRZ76_RS23680 (4928306) 4928306..4930444 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LRZ76_RS23685 (4930773) 4930773..4931237 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRZ76_RS23690 (4931241) 4931241..4931525 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRZ76_RS23695 (4931515) 4931515..4931757 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRZ76_RS23700 (4931835) 4931835..4933745 - 1911 WP_012737231.1 PRD domain-containing protein -
LRZ76_RS23705 (4933768) 4933768..4934922 - 1155 WP_012737230.1 lactonase family protein -
LRZ76_RS23710 (4934989) 4934989..4935729 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T227399 WP_004178374.1 NZ_CP089021:c4931525-4931241 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T227399 NZ_CP122868:293109-293339 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT227399 WP_002886901.1 NZ_CP089021:c4931757-4931515 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT227399 NZ_CP122868:293336-293695 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References