22739

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4803153..4803748 Replicon chromosome
Accession NC_010498
Organism Escherichia coli SMS-3-5

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag ECSMS35_RS23645 Protein ID WP_000239581.1
Coordinates 4803398..4803748 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag ECSMS35_RS23640 Protein ID WP_001223213.1
Coordinates 4803153..4803404 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECSMS35_RS23630 4798818..4802597 + 3780 WP_000060872.1 autotransporter assembly complex protein TamB -
ECSMS35_RS23635 4802600..4802941 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
ECSMS35_RS23640 4803153..4803404 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
ECSMS35_RS23645 4803398..4803748 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
ECSMS35_RS23650 4803827..4804357 - 531 WP_000055075.1 inorganic diphosphatase -
ECSMS35_RS23655 4804667..4805623 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
ECSMS35_RS23660 4805756..4807258 + 1503 WP_001095664.1 sugar ABC transporter ATP-binding protein -
ECSMS35_RS23665 4807272..4808294 + 1023 WP_012311695.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T22739 WP_000239581.1 NC_010498:4803398-4803748 [Escherichia coli SMS-3-5]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T22739 NC_010498:4803398-4803748 [Escherichia coli SMS-3-5]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT22739 WP_001223213.1 NC_010498:4803153-4803404 [Escherichia coli SMS-3-5]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT22739 NC_010498:4803153-4803404 [Escherichia coli SMS-3-5]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References