Detailed information of TA system TA022739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 4803153..4803748
• Replicon: chromosome
• Accession: NC_010498
• Organism: Escherichia coli SMS-3-5

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: ECSMS35_RS23645
• Protein ID: WP_000239581.1
• Coordinates: 4803398..4803748 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: ECSMS35_RS23640
• Protein ID: WP_001223213.1
• Coordinates: 4803153..4803404 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECSMS35_RS23630	4798818..4802597	+	3780	WP_000060872.1	autotransporter assembly complex protein TamB	-
ECSMS35_RS23635	4802600..4802941	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
ECSMS35_RS23640	4803153..4803404	+	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
ECSMS35_RS23645	4803398..4803748	+	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
ECSMS35_RS23650	4803827..4804357	-	531	WP_000055075.1	inorganic diphosphatase	-
ECSMS35_RS23655	4804667..4805623	+	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
ECSMS35_RS23660	4805756..4807258	+	1503	WP_001095664.1	sugar ABC transporter ATP-binding protein	-
ECSMS35_RS23665	4807272..4808294	+	1023	WP_012311695.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T22739 WP_000239581.1 NC_010498:4803398-4803748 [Escherichia coli SMS-3-5]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T22739 NC_010498:4803398-4803748 [Escherichia coli SMS-3-5]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT22739 WP_001223213.1 NC_010498:4803153-4803404 [Escherichia coli SMS-3-5]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT22739 NC_010498:4803153-4803404 [Escherichia coli SMS-3-5]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7