Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797661..798318 Replicon chromosome
Accession NZ_CP089021
Organism Klebsiella pneumoniae strain 53370

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LRZ76_RS03960 Protein ID WP_002916310.1
Coordinates 797908..798318 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LRZ76_RS03955 Protein ID WP_002916312.1
Coordinates 797661..797927 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ76_RS03930 (792869) 792869..794302 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LRZ76_RS03935 (794421) 794421..795149 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
LRZ76_RS03940 (795199) 795199..795510 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LRZ76_RS03945 (795674) 795674..796333 + 660 WP_002916317.1 hemolysin III family protein -
LRZ76_RS03950 (796432) 796432..797415 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
LRZ76_RS03955 (797661) 797661..797927 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LRZ76_RS03960 (797908) 797908..798318 + 411 WP_002916310.1 protein YgfX Toxin
LRZ76_RS03965 (798325) 798325..798846 - 522 WP_002916308.1 flavodoxin FldB -
LRZ76_RS03970 (798947) 798947..799843 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LRZ76_RS03975 (799866) 799866..800579 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRZ76_RS03980 (800585) 800585..802318 + 1734 WP_094953199.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T227387 WP_002916310.1 NZ_CP089021:797908-798318 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T227387 NZ_CP122859:c4232501-4232328 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT227387 WP_002916312.1 NZ_CP089021:797661-797927 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227387 NZ_CP122859:c4232825-4232529 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References