Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 88315..89225 Replicon plasmid p53374-204.7
Accession NZ_CP089020
Organism Klebsiella pneumoniae strain 53374

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag LRZ80_RS29770 Protein ID WP_004026354.1
Coordinates 88315..88785 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LRZ80_RS29775 Protein ID WP_231828928.1
Coordinates 88782..89225 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ80_RS29750 (LRZ80_29755) 83986..84480 - 495 WP_004212794.1 thermonuclease family protein -
LRZ80_RS29755 (LRZ80_29760) 84658..84924 + 267 WP_223175074.1 DUF1173 family protein -
LRZ80_RS29760 (LRZ80_29765) 84957..85607 + 651 WP_223356693.1 DUF1173 family protein -
LRZ80_RS29770 (LRZ80_29775) 88315..88785 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
LRZ80_RS29775 (LRZ80_29780) 88782..89225 - 444 WP_231828928.1 DUF2384 domain-containing protein Antitoxin
LRZ80_RS29780 (LRZ80_29785) 89326..89829 - 504 Protein_89 DUF4113 domain-containing protein -
LRZ80_RS29785 (LRZ80_29790) 89927..90148 - 222 WP_004213643.1 DUF2188 domain-containing protein -
LRZ80_RS29790 (LRZ80_29795) 90323..90448 - 126 Protein_91 Fe3+-citrate ABC transporter substrate-binding protein -
LRZ80_RS29795 (LRZ80_29800) 90523..92649 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
LRZ80_RS29800 (LRZ80_29805) 92736..93689 - 954 Protein_93 fec operon regulator FecR -
LRZ80_RS29805 (LRZ80_29810) 93686..94207 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA / pla 1..204725 204725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(16-147)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T227383 WP_004026354.1 NZ_CP089020:c88785-88315 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T227383 NZ_CP122859:2663991-2664098 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16470.76 Da        Isoelectric Point: 10.2498

>AT227383 WP_231828928.1 NZ_CP089020:c89225-88782 [Klebsiella pneumoniae]
MKTFSLSSTPARSQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT227383 NZ_CP122859:c2663944-2663878 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure

References