Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4825026..4825542 Replicon chromosome
Accession NZ_CP089014
Organism Klebsiella pneumoniae strain 53374

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LRZ80_RS23910 Protein ID WP_002886902.1
Coordinates 4825026..4825310 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LRZ80_RS23915 Protein ID WP_002886901.1
Coordinates 4825300..4825542 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ80_RS23885 (LRZ80_23890) 4820510..4820773 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LRZ80_RS23890 (LRZ80_23895) 4820903..4821076 + 174 WP_002886906.1 hypothetical protein -
LRZ80_RS23895 (LRZ80_23900) 4821079..4821822 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LRZ80_RS23900 (LRZ80_23905) 4822179..4824317 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LRZ80_RS23905 (LRZ80_23910) 4824558..4825022 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRZ80_RS23910 (LRZ80_23915) 4825026..4825310 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRZ80_RS23915 (LRZ80_23920) 4825300..4825542 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRZ80_RS23920 (LRZ80_23925) 4825620..4827530 - 1911 WP_004152270.1 PRD domain-containing protein -
LRZ80_RS23925 (LRZ80_23930) 4827553..4828707 - 1155 WP_002886900.1 lactonase family protein -
LRZ80_RS23930 (LRZ80_23935) 4828773..4829513 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T227377 WP_002886902.1 NZ_CP089014:c4825310-4825026 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T227377 NZ_CP122859:1806294-1806548 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT227377 WP_002886901.1 NZ_CP089014:c4825542-4825300 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT227377 NZ_CP122859:1806046-1806297 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References