Detailed information of TA system TA022737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3836592..3837235
• Replicon: chromosome
• Accession: NC_010498
• Organism: Escherichia coli SMS-3-5

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ECSMS35_RS19045
• Protein ID: WP_049038273.1
• Coordinates: 3836948..3837235 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: U9Y7E1
• Locus tag: ECSMS35_RS19040
• Protein ID: WP_000593555.1
• Coordinates: 3836592..3836951 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECSMS35_RS19010	3831707..3832180	+	474	WP_012311717.1	PTS sugar transporter subunit IIA	-
ECSMS35_RS19015	3832177..3832458	+	282	WP_000084021.1	PTS sugar transporter subunit IIB	-
ECSMS35_RS19020	3832532..3833890	+	1359	WP_001302220.1	PTS galactitol transporter subunit IIC	-
ECSMS35_RS19025	3833883..3835391	+	1509	WP_012311797.1	carbohydrate kinase	-
ECSMS35_RS19030	3835381..3835650	+	270	WP_000949581.1	HPr family phosphocarrier protein	-
ECSMS35_RS19035	3835682..3836542	+	861	WP_001131792.1	class II aldolase	-
ECSMS35_RS19040	3836592..3836951	-	360	WP_000593555.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ECSMS35_RS19045	3836948..3837235	-	288	WP_049038273.1	type II toxin-antitoxin system HicA family toxin	Toxin
ECSMS35_RS19050	3837295..3838419	-	1125	WP_001314210.1	ABC transporter permease	-
ECSMS35_RS19055	3838419..3841154	-	2736	WP_000149118.1	ribosome-associated ATPase/putative transporter RbbA	-
ECSMS35_RS19060	3841151..3842218	-	1068	WP_000361481.1	HlyD family efflux transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (34-84)

Antitoxin

• Uncharacterised protein family HicB (60-112)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10490.98 Da
• Isoelectric Point: 7.7845

>T22737 WP_049038273.1 NC_010498:c3837235-3836948 [Escherichia coli SMS-3-5]
IRTCHENPGTGFTEETKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGA
VESVRDWLLSIGVKP

Nucleotide

• Length: 288 bp

>T22737 NC_010498:c3837235-3836948 [Escherichia coli SMS-3-5]
ATAAGGACATGCCATGAGAACCCTGGTACAGGCTTTACGGAAGAAACAAAAAATACATTGGATCAAATATTTAAATCTCC
TGTTCCTCAAGGGATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTT
CGCGTTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCT
GTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13402.27 Da
• Isoelectric Point: 5.1987

>AT22737 WP_000593555.1 NC_010498:c3836951-3836592 [Escherichia coli SMS-3-5]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Nucleotide

• Length: 360 bp

>AT22737 NC_010498:c3836951-3836592 [Escherichia coli SMS-3-5]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U9LKZ6