Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870324..870981 Replicon chromosome
Accession NZ_CP089014
Organism Klebsiella pneumoniae strain 53374

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LRZ80_RS04400 Protein ID WP_002916310.1
Coordinates 870571..870981 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LRZ80_RS04395 Protein ID WP_002916312.1
Coordinates 870324..870590 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ80_RS04370 (LRZ80_04370) 865480..866913 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LRZ80_RS04375 (LRZ80_04375) 867032..867760 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LRZ80_RS04380 (LRZ80_04380) 867810..868121 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LRZ80_RS04385 (LRZ80_04385) 868285..868944 + 660 WP_002916317.1 hemolysin III family protein -
LRZ80_RS04390 (LRZ80_04390) 869095..870078 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LRZ80_RS04395 (LRZ80_04395) 870324..870590 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LRZ80_RS04400 (LRZ80_04400) 870571..870981 + 411 WP_002916310.1 protein YgfX Toxin
LRZ80_RS04405 (LRZ80_04405) 870988..871509 - 522 WP_002916308.1 flavodoxin FldB -
LRZ80_RS04410 (LRZ80_04410) 871610..872506 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LRZ80_RS04415 (LRZ80_04415) 872529..873242 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRZ80_RS04420 (LRZ80_04420) 873248..874981 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T227365 WP_002916310.1 NZ_CP089014:870571-870981 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T227365 NZ_CP122849:c25014-24598 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT227365 WP_002916312.1 NZ_CP089014:870324-870590 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227365 NZ_CP122849:c25241-25011 [Escherichia coli]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References