Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 139517..140187 | Replicon | plasmid p56575-208.5 |
| Accession | NZ_CP089013 | ||
| Organism | Klebsiella pneumoniae strain 56575 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q6U619 |
| Locus tag | LRZ79_RS25730 | Protein ID | WP_004213072.1 |
| Coordinates | 139517..139960 (-) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q6U620 |
| Locus tag | LRZ79_RS25735 | Protein ID | WP_004213073.1 |
| Coordinates | 139957..140187 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRZ79_RS25695 (LRZ79_25695) | 134930..135205 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
| LRZ79_RS25700 (LRZ79_25700) | 135268..135759 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
| LRZ79_RS25705 (LRZ79_25705) | 135808..136728 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
| LRZ79_RS25710 (LRZ79_25710) | 136819..137222 | + | 404 | Protein_146 | GAF domain-containing protein | - |
| LRZ79_RS25715 (LRZ79_25715) | 137739..138373 | - | 635 | Protein_147 | mucoid phenotype regulator RmpA2 | - |
| LRZ79_RS25720 (LRZ79_25720) | 138790..139094 | + | 305 | Protein_148 | transposase | - |
| LRZ79_RS25725 (LRZ79_25725) | 139117..139368 | - | 252 | WP_186987481.1 | hypothetical protein | - |
| LRZ79_RS25730 (LRZ79_25730) | 139517..139960 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LRZ79_RS25735 (LRZ79_25735) | 139957..140187 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LRZ79_RS25740 (LRZ79_25740) | 140795..141928 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
| LRZ79_RS25745 (LRZ79_25745) | 141944..142237 | + | 294 | WP_004213076.1 | hypothetical protein | - |
| LRZ79_RS25750 (LRZ79_25750) | 142227..142433 | - | 207 | WP_004213077.1 | hypothetical protein | - |
| LRZ79_RS25755 (LRZ79_25755) | 142785..143075 | + | 291 | WP_004213078.1 | hypothetical protein | - |
| LRZ79_RS25760 (LRZ79_25760) | 143065..143964 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
| LRZ79_RS25765 (LRZ79_25765) | 144013..144669 | - | 657 | WP_231798523.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / rmpA | 1..208529 | 208529 | |
| - | flank | IS/Tn | - | - | 144707..145675 | 968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T227360 WP_004213072.1 NZ_CP089013:c139960-139517 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T227360 NZ_CP122844:c4050351-4049974 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCTGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGTCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCTGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGTCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT227360 WP_004213073.1 NZ_CP089013:c140187-139957 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT227360 NZ_CP122844:c4050809-4050441 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGAGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGAGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|