Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4743195..4744876 Replicon chromosome
Accession NZ_CP089012
Organism Klebsiella pneumoniae strain 56575

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag LRZ79_RS23155 Protein ID WP_002885155.1
Coordinates 4743195..4744112 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2L1C4M5
Locus tag LRZ79_RS23160 Protein ID WP_004192584.1
Coordinates 4744118..4744876 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ79_RS23135 (4738501) 4738501..4740021 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
LRZ79_RS23140 (4740018) 4740018..4741016 + 999 WP_004146665.1 ribose ABC transporter permease -
LRZ79_RS23145 (4741047) 4741047..4741988 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
LRZ79_RS23150 (4742063) 4742063..4743070 + 1008 WP_004210019.1 carbohydrate kinase family protein -
LRZ79_RS23155 (4743195) 4743195..4744112 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LRZ79_RS23160 (4744118) 4744118..4744876 - 759 WP_004192584.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
LRZ79_RS23165 (4744962) 4744962..4745690 - 729 WP_004210017.1 response regulator transcription factor -
LRZ79_RS23170 (4745963) 4745963..4748110 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
LRZ79_RS23175 (4748340) 4748340..4749026 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T227356 WP_002885155.1 NZ_CP089012:c4744112-4743195 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T227356 NZ_CP122844:2660991-2661098 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28582.94 Da        Isoelectric Point: 10.0870

>AT227356 WP_004192584.1 NZ_CP089012:c4744876-4744118 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT227356 NZ_CP122844:c2660944-2660878 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1C4M5

References