Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
Location | 4743195..4744876 | Replicon | chromosome |
Accession | NZ_CP089012 | ||
Organism | Klebsiella pneumoniae strain 56575 |
Toxin (Protein)
Gene name | mosT | Uniprot ID | W8V1Q6 |
Locus tag | LRZ79_RS23155 | Protein ID | WP_002885155.1 |
Coordinates | 4743195..4744112 (-) | Length | 306 a.a. |
Antitoxin (Protein)
Gene name | mosA | Uniprot ID | A0A2L1C4M5 |
Locus tag | LRZ79_RS23160 | Protein ID | WP_004192584.1 |
Coordinates | 4744118..4744876 (-) | Length | 253 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LRZ79_RS23135 (4738501) | 4738501..4740021 | + | 1521 | WP_004210021.1 | sugar ABC transporter ATP-binding protein | - |
LRZ79_RS23140 (4740018) | 4740018..4741016 | + | 999 | WP_004146665.1 | ribose ABC transporter permease | - |
LRZ79_RS23145 (4741047) | 4741047..4741988 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
LRZ79_RS23150 (4742063) | 4742063..4743070 | + | 1008 | WP_004210019.1 | carbohydrate kinase family protein | - |
LRZ79_RS23155 (4743195) | 4743195..4744112 | - | 918 | WP_002885155.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
LRZ79_RS23160 (4744118) | 4744118..4744876 | - | 759 | WP_004192584.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
LRZ79_RS23165 (4744962) | 4744962..4745690 | - | 729 | WP_004210017.1 | response regulator transcription factor | - |
LRZ79_RS23170 (4745963) | 4745963..4748110 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
LRZ79_RS23175 (4748340) | 4748340..4749026 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34687.15 Da Isoelectric Point: 5.4707
>T227356 WP_002885155.1 NZ_CP089012:c4744112-4743195 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T227356 NZ_CP122844:2660991-2661098 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28582.94 Da Isoelectric Point: 10.0870
>AT227356 WP_004192584.1 NZ_CP089012:c4744876-4744118 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT227356 NZ_CP122844:c2660944-2660878 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GH11 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2L1C4M5 |