227355

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4585428..4585944 Replicon chromosome
Accession NZ_CP089012
Organism Klebsiella pneumoniae strain 56575

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag LRZ79_RS22360 Protein ID WP_009309309.1
Coordinates 4585428..4585712 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LRZ79_RS22365 Protein ID WP_002886901.1
Coordinates 4585702..4585944 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ79_RS22335 (4580845) 4580845..4581108 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LRZ79_RS22340 (4581238) 4581238..4581411 + 174 WP_002886906.1 hypothetical protein -
LRZ79_RS22345 (4581414) 4581414..4582157 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LRZ79_RS22350 (4582514) 4582514..4584652 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LRZ79_RS22355 (4584960) 4584960..4585424 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRZ79_RS22360 (4585428) 4585428..4585712 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRZ79_RS22365 (4585702) 4585702..4585944 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRZ79_RS22370 (4586022) 4586022..4587932 - 1911 WP_004152270.1 PRD domain-containing protein -
LRZ79_RS22375 (4587955) 4587955..4589109 - 1155 WP_064148391.1 lactonase family protein -
LRZ79_RS22380 (4589176) 4589176..4589916 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T227355 WP_009309309.1 NZ_CP089012:c4585712-4585428 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T227355 NZ_CP122844:2660456-2660563 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT227355 WP_002886901.1 NZ_CP089012:c4585944-4585702 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT227355 NZ_CP122844:c2660409-2660343 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References