Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3860347..3860966 Replicon chromosome
Accession NZ_CP089012
Organism Klebsiella pneumoniae strain 56575

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LRZ79_RS18940 Protein ID WP_002892050.1
Coordinates 3860748..3860966 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LRZ79_RS18935 Protein ID WP_002892066.1
Coordinates 3860347..3860721 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ79_RS18925 (3855499) 3855499..3856692 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LRZ79_RS18930 (3856715) 3856715..3859861 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LRZ79_RS18935 (3860347) 3860347..3860721 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LRZ79_RS18940 (3860748) 3860748..3860966 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LRZ79_RS18945 (3861125) 3861125..3861691 + 567 WP_002892030.1 maltose O-acetyltransferase -
LRZ79_RS18950 (3861663) 3861663..3861803 - 141 WP_004147370.1 hypothetical protein -
LRZ79_RS18955 (3861824) 3861824..3862294 + 471 WP_002892026.1 YlaC family protein -
LRZ79_RS18960 (3862269) 3862269..3863720 - 1452 WP_004213726.1 PLP-dependent aminotransferase family protein -
LRZ79_RS18965 (3863821) 3863821..3864519 + 699 WP_004177238.1 GNAT family protein -
LRZ79_RS18970 (3864516) 3864516..3864656 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LRZ79_RS18975 (3864656) 3864656..3864919 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T227352 WP_002892050.1 NZ_CP089012:3860748-3860966 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T227352 NZ_CP122844:2305410-2305697 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT227352 WP_002892066.1 NZ_CP089012:3860347-3860721 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT227352 NZ_CP122844:2305171-2305410 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References