Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
| Location | 1725820..1726410 | Replicon | chromosome |
| Accession | NZ_CP089012 | ||
| Organism | Klebsiella pneumoniae strain 56575 | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | A0A2L1BXX2 |
| Locus tag | LRZ79_RS08280 | Protein ID | WP_022615588.1 |
| Coordinates | 1726078..1726410 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | A0A3S7DDD0 |
| Locus tag | LRZ79_RS08275 | Protein ID | WP_000288812.1 |
| Coordinates | 1725820..1726077 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRZ79_RS08250 (1721090) | 1721090..1722838 | + | 1749 | WP_023302666.1 | hypothetical protein | - |
| LRZ79_RS08255 (1722917) | 1722917..1723473 | + | 557 | Protein_1614 | hypothetical protein | - |
| LRZ79_RS08260 (1723754) | 1723754..1724722 | + | 969 | WP_004225014.1 | IS5 family transposase | - |
| LRZ79_RS08265 (1724821) | 1724821..1725282 | + | 462 | WP_004213450.1 | hypothetical protein | - |
| LRZ79_RS08270 (1725279) | 1725279..1725485 | + | 207 | WP_022615589.1 | helix-turn-helix transcriptional regulator | - |
| LRZ79_RS08275 (1725820) | 1725820..1726077 | + | 258 | WP_000288812.1 | antitoxin | Antitoxin |
| LRZ79_RS08280 (1726078) | 1726078..1726410 | + | 333 | WP_022615588.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LRZ79_RS08290 (1726732) | 1726732..1728168 | + | 1437 | WP_004151469.1 | EmmdR/YeeO family multidrug/toxin efflux MATE transporter | - |
| LRZ79_RS08300 (1728534) | 1728534..1729988 | - | 1455 | WP_004148975.1 | AMP nucleosidase | - |
| LRZ79_RS08305 (1730118) | 1730118..1730363 | - | 246 | WP_004141189.1 | signal transduction protein PmrD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1723799..1724722 | 923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11913.80 Da Isoelectric Point: 10.1839
>T227342 WP_022615588.1 NZ_CP089012:1726078-1726410 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDVVVNEVLARLDAMLS
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDVVVNEVLARLDAMLS
Download Length: 333 bp
>T227342 NZ_CP122844:178133-178240 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9442.92 Da Isoelectric Point: 4.3566
>AT227342 WP_000288812.1 NZ_CP089012:1725820-1726077 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL
Download Length: 258 bp
>AT227342 NZ_CP122844:c178085-178019 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2L1BXX2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S7DDD0 |