227341

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 796024..796681 Replicon chromosome
Accession NZ_CP089012
Organism Klebsiella pneumoniae strain 56575

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LRZ79_RS03940 Protein ID WP_002916310.1
Coordinates 796271..796681 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LRZ79_RS03935 Protein ID WP_002916312.1
Coordinates 796024..796290 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ79_RS03910 (791181) 791181..792614 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LRZ79_RS03915 (792733) 792733..793461 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LRZ79_RS03920 (793510) 793510..793821 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LRZ79_RS03925 (793985) 793985..794644 + 660 WP_002916317.1 hemolysin III family protein -
LRZ79_RS03930 (794795) 794795..795778 - 984 WP_022615657.1 tRNA-modifying protein YgfZ -
LRZ79_RS03935 (796024) 796024..796290 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LRZ79_RS03940 (796271) 796271..796681 + 411 WP_002916310.1 protein YgfX Toxin
LRZ79_RS03945 (796688) 796688..797209 - 522 WP_002916308.1 flavodoxin FldB -
LRZ79_RS03950 (797310) 797310..798206 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LRZ79_RS03955 (798229) 798229..798942 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRZ79_RS03960 (798948) 798948..800681 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T227341 WP_002916310.1 NZ_CP089012:796271-796681 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T227341 NZ_CP122843:c94828-94676 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT227341 WP_002916312.1 NZ_CP089012:796024-796290 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227341 NZ_CP122843:94878-94940 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References