227330

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4785711..4786227 Replicon chromosome
Accession NZ_CP089001
Organism Klebsiella pneumoniae strain 56661

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LRZ77_RS23550 Protein ID WP_009486548.1
Coordinates 4785711..4785995 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LRZ77_RS23555 Protein ID WP_002886901.1
Coordinates 4785985..4786227 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ77_RS23525 (4781128) 4781128..4781391 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LRZ77_RS23530 (4781521) 4781521..4781694 + 174 WP_032433782.1 hypothetical protein -
LRZ77_RS23535 (4781697) 4781697..4782440 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LRZ77_RS23540 (4782797) 4782797..4784935 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LRZ77_RS23545 (4785243) 4785243..4785707 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRZ77_RS23550 (4785711) 4785711..4785995 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRZ77_RS23555 (4785985) 4785985..4786227 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRZ77_RS23560 (4786305) 4786305..4788215 - 1911 WP_009486549.1 PRD domain-containing protein -
LRZ77_RS23565 (4788238) 4788238..4789392 - 1155 WP_002886900.1 lactonase family protein -
LRZ77_RS23570 (4789459) 4789459..4790199 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T227330 WP_009486548.1 NZ_CP089001:c4785995-4785711 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T227330 NZ_CP122837:2762541-2762648 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT227330 WP_002886901.1 NZ_CP089001:c4786227-4785985 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT227330 NZ_CP122837:c2762491-2762428 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References