227329

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4697817..4698652 Replicon chromosome
Accession NZ_CP089001
Organism Klebsiella pneumoniae strain 56661

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5E2RWI0
Locus tag LRZ77_RS23180 Protein ID WP_001559913.1
Coordinates 4697817..4698194 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5E3EVB5
Locus tag LRZ77_RS23185 Protein ID WP_032408847.1
Coordinates 4698284..4698652 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ77_RS23145 (4693777) 4693777..4693965 - 189 Protein_4544 transposase -
LRZ77_RS23150 (4693982) 4693982..4695093 - 1112 Protein_4545 IS3 family transposase -
LRZ77_RS23155 (4695545) 4695545..4695694 - 150 Protein_4546 restriction endonuclease subunit M -
LRZ77_RS23160 (4695779) 4695779..4695976 - 198 WP_032408848.1 DUF957 domain-containing protein -
LRZ77_RS23165 (4695996) 4695996..4696238 - 243 Protein_4548 DUF5983 family protein -
LRZ77_RS23170 (4696325) 4696325..4697553 + 1229 WP_089541817.1 IS3 family transposase -
LRZ77_RS23175 (4697563) 4697563..4697820 - 258 Protein_4550 DUF5983 family protein -
LRZ77_RS23180 (4697817) 4697817..4698194 - 378 WP_001559913.1 TA system toxin CbtA family protein Toxin
LRZ77_RS23185 (4698284) 4698284..4698652 - 369 WP_032408847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LRZ77_RS23190 (4698829) 4698829..4699050 - 222 WP_000692300.1 DUF987 domain-containing protein -
LRZ77_RS23195 (4699119) 4699119..4699595 - 477 WP_032408846.1 RadC family protein -
LRZ77_RS23200 (4699610) 4699610..4700095 - 486 WP_088607457.1 antirestriction protein -
LRZ77_RS23205 (4700187) 4700187..4701005 - 819 WP_001559911.1 DUF932 domain-containing protein -
LRZ77_RS23210 (4701105) 4701105..4701338 - 234 WP_001119729.1 DUF905 family protein -
LRZ77_RS23215 (4701417) 4701417..4701872 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4685856..4716608 30752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14148.10 Da        Isoelectric Point: 7.8276

>T227329 WP_001559913.1 NZ_CP089001:c4698194-4697817 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T227329 NZ_CP122837:2762006-2762113 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13682.62 Da        Isoelectric Point: 7.8398

>AT227329 WP_032408847.1 NZ_CP089001:c4698652-4698284 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT227329 NZ_CP122837:c2761953-2761892 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E2RWI0

Antitoxin

Source ID Structure
AlphaFold DB A0A5E3EVB5

References