Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1457411..1458054 Replicon chromosome
Accession NZ_CP089001
Organism Klebsiella pneumoniae strain 56661

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag LRZ77_RS07185 Protein ID WP_032433387.1
Coordinates 1457638..1458054 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LRZ77_RS07180 Protein ID WP_001261276.1
Coordinates 1457411..1457641 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ77_RS07165 (1452433) 1452433..1453520 + 1088 Protein_1400 transcriptional regulator -
LRZ77_RS07170 (1453523) 1453523..1455763 + 2241 WP_045326788.1 P-loop NTPase fold protein -
LRZ77_RS07175 (1456291) 1456291..1457106 - 816 WP_032433388.1 hypothetical protein -
LRZ77_RS07180 (1457411) 1457411..1457641 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LRZ77_RS07185 (1457638) 1457638..1458054 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
LRZ77_RS07190 (1458210) 1458210..1459190 + 981 WP_032433385.1 hypothetical protein -
LRZ77_RS07195 (1459385) 1459385..1460956 - 1572 WP_032433383.1 AAA family ATPase -
LRZ77_RS07200 (1461275) 1461275..1461523 + 249 WP_032433382.1 hypothetical protein -
LRZ77_RS07205 (1461582) 1461582..1462100 + 519 WP_045326794.1 hypothetical protein -
LRZ77_RS07210 (1462131) 1462131..1462622 + 492 WP_032433378.1 hypothetical protein -
LRZ77_RS07215 (1462682) 1462682..1462885 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1442047..1488544 46497


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T227316 WP_032433387.1 NZ_CP089001:1457638-1458054 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T227316 NZ_CP122834:c162874-162587 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCAGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT227316 WP_001261276.1 NZ_CP089001:1457411-1457641 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT227316 NZ_CP122834:c163122-162871 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTGGACCTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References