227315

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 838118..838775 Replicon chromosome
Accession NZ_CP089001
Organism Klebsiella pneumoniae strain 56661

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LRZ77_RS04195 Protein ID WP_002916310.1
Coordinates 838365..838775 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LRZ77_RS04190 Protein ID WP_002916312.1
Coordinates 838118..838384 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ77_RS04165 (833695) 833695..834675 - 981 WP_000019402.1 IS5-like element IS5 family transposase -
LRZ77_RS04170 (834826) 834826..835554 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LRZ77_RS04175 (835604) 835604..835915 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LRZ77_RS04180 (836079) 836079..836738 + 660 WP_002916317.1 hemolysin III family protein -
LRZ77_RS04185 (836889) 836889..837872 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LRZ77_RS04190 (838118) 838118..838384 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LRZ77_RS04195 (838365) 838365..838775 + 411 WP_002916310.1 protein YgfX Toxin
LRZ77_RS04200 (838782) 838782..839303 - 522 WP_004144730.1 flavodoxin FldB -
LRZ77_RS04205 (839404) 839404..840300 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LRZ77_RS04210 (840323) 840323..841036 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRZ77_RS04215 (841042) 841042..842775 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 833695..834675 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T227315 WP_002916310.1 NZ_CP089001:838365-838775 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T227315 NZ_CP122834:c135586-135320 [Escherichia coli]
ATGAAGGTACGAAAAGGTGACAGGCAATATTATTTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGGAAAACAAAAGCGACAGTGATAACTGTTGCCGATCTGATTTTTCATGAAGATGCAT
TCGACACTATCGACTTTACCAGAGGCGGGTTAAGAGAGAACGACAAAGAAGTTGTTTCTATGATGATTCAGGAAATGAAC
AATGAACGAGAAAAAAATGTTAACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT227315 WP_002916312.1 NZ_CP089001:838118-838384 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227315 NZ_CP122834:c135330-135088 [Escherichia coli]
ATGTTAACTGAAAATACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACGCAAAGAGAATGTGCTGAAAT
ATTCAGCATGAACCCGCGAACCTGGCGTCGCAAGGAAGAACCTGCCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATATCTTCAGCTTTTAGCTGGGGAACATCCTGAATACGTTCTGCGCAAAAGGGATAAACCTAAATGTAGTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References