Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876967..877621 Replicon chromosome
Accession NZ_CP088997
Organism Klebsiella pneumoniae strain 49088

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LRZ82_RS04435 Protein ID WP_004144731.1
Coordinates 877214..877621 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LRZ82_RS04430 Protein ID WP_002916312.1
Coordinates 876967..877233 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ82_RS04405 (LRZ82_04405) 872123..873556 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LRZ82_RS04410 (LRZ82_04410) 873675..874403 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LRZ82_RS04415 (LRZ82_04415) 874453..874764 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LRZ82_RS04420 (LRZ82_04420) 874928..875587 + 660 WP_002916317.1 hemolysin III family protein -
LRZ82_RS04425 (LRZ82_04425) 875738..876721 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LRZ82_RS04430 (LRZ82_04430) 876967..877233 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LRZ82_RS04435 (LRZ82_04435) 877214..877621 + 408 WP_004144731.1 protein YgfX Toxin
LRZ82_RS04440 (LRZ82_04440) 877628..878149 - 522 WP_002916308.1 flavodoxin FldB -
LRZ82_RS04445 (LRZ82_04445) 878250..879146 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LRZ82_RS04450 (LRZ82_04450) 879169..879882 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRZ82_RS04455 (LRZ82_04455) 879888..881621 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T227290 WP_004144731.1 NZ_CP088997:877214-877621 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T227290 NZ_CP122827:53645-53905 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCTGATCTTGTTTTTCATGAGGAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGC
GAGGGAAAAAATGCTAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT227290 WP_002916312.1 NZ_CP088997:876967-877233 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227290 NZ_CP122827:53895-54146 [Escherichia coli]
ATGCTAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTCAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTCCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References