Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4915461..4915977 Replicon chromosome
Accession NZ_CP088991
Organism Klebsiella pneumoniae strain 50700

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LRZ81_RS24365 Protein ID WP_002886902.1
Coordinates 4915461..4915745 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LRZ81_RS24370 Protein ID WP_002886901.1
Coordinates 4915735..4915977 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ81_RS24340 (LRZ81_24340) 4910945..4911208 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LRZ81_RS24345 (LRZ81_24345) 4911338..4911511 + 174 WP_002886906.1 hypothetical protein -
LRZ81_RS24350 (LRZ81_24350) 4911514..4912257 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LRZ81_RS24355 (LRZ81_24355) 4912614..4914752 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LRZ81_RS24360 (LRZ81_24360) 4914993..4915457 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRZ81_RS24365 (LRZ81_24365) 4915461..4915745 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRZ81_RS24370 (LRZ81_24370) 4915735..4915977 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRZ81_RS24375 (LRZ81_24375) 4916055..4917965 - 1911 WP_004152270.1 PRD domain-containing protein -
LRZ81_RS24380 (LRZ81_24380) 4917988..4919142 - 1155 WP_002886900.1 lactonase family protein -
LRZ81_RS24385 (LRZ81_24385) 4919208..4919948 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T227276 WP_002886902.1 NZ_CP088991:c4915745-4915461 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T227276 NZ_CP122823:1043588-1043923 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT227276 WP_002886901.1 NZ_CP088991:c4915977-4915735 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT227276 NZ_CP122823:1043340-1043588 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References