Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2740351..2741939 Replicon chromosome
Accession NZ_CP088991
Organism Klebsiella pneumoniae strain 50700

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag LRZ81_RS13590 Protein ID WP_004199851.1
Coordinates 2740351..2741673 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LRZ81_RS13595 Protein ID WP_002904790.1
Coordinates 2741673..2741939 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ81_RS13575 (LRZ81_13575) 2735416..2737917 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
LRZ81_RS13580 (LRZ81_13580) 2737905..2738909 + 1005 WP_004199852.1 fimbrial protein -
LRZ81_RS13585 (LRZ81_13585) 2739042..2740334 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LRZ81_RS13590 (LRZ81_13590) 2740351..2741673 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
LRZ81_RS13595 (LRZ81_13595) 2741673..2741939 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LRZ81_RS13600 (LRZ81_13600) 2742205..2742531 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LRZ81_RS13605 (LRZ81_13605) 2742528..2743028 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LRZ81_RS13610 (LRZ81_13610) 2743006..2744385 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
LRZ81_RS13615 (LRZ81_13615) 2744731..2745885 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LRZ81_RS13620 (LRZ81_13620) 2745866..2746789 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(149-402)

Antitoxin

(16-65)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T227273 WP_004199851.1 NZ_CP088991:c2741673-2740351 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T227273 NZ_CP122823:686243-686557 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT227273 WP_002904790.1 NZ_CP088991:c2741939-2741673 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT227273 NZ_CP122823:686554-686970 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References