Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2500023..2501611 Replicon chromosome
Accession NZ_CP088985
Organism Klebsiella pneumoniae strain 53334

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LRZ83_RS12255 Protein ID WP_040211308.1
Coordinates 2500023..2501345 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LRZ83_RS12260 Protein ID WP_040216240.1
Coordinates 2501345..2501611 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ83_RS12240 (LRZ83_12240) 2495080..2497581 + 2502 WP_073557771.1 fimbria/pilus outer membrane usher protein -
LRZ83_RS12245 (LRZ83_12245) 2497569..2498573 + 1005 WP_021462558.1 fimbrial protein -
LRZ83_RS12250 (LRZ83_12250) 2498714..2500006 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LRZ83_RS12255 (LRZ83_12255) 2500023..2501345 - 1323 WP_040211308.1 type II toxin-antitoxin system HipA family toxin Toxin
LRZ83_RS12260 (LRZ83_12260) 2501345..2501611 - 267 WP_040216240.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LRZ83_RS12265 (LRZ83_12265) 2501997..2502323 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LRZ83_RS12270 (LRZ83_12270) 2502320..2502820 - 501 WP_023285113.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LRZ83_RS12275 (LRZ83_12275) 2502798..2504177 - 1380 WP_073557772.1 nucleobase:cation symporter-2 family protein -
LRZ83_RS12280 (LRZ83_12280) 2504523..2505677 + 1155 WP_117024249.1 FAD-dependent urate hydroxylase HpxO -
LRZ83_RS12285 (LRZ83_12285) 2505658..2506581 - 924 WP_073557774.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2307992..2542275 234283


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49099.40 Da        Isoelectric Point: 7.8897

>T227228 WP_040211308.1 NZ_CP088985:c2501345-2500023 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARGLGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T227228 NZ_CP122801:3050149-3050256 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9959.39 Da        Isoelectric Point: 8.6103

>AT227228 WP_040216240.1 NZ_CP088985:c2501611-2501345 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DHNTDLDW

Download         Length: 267 bp

>AT227228 NZ_CP122801:c3050102-3050036 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References