Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 962678..963335 Replicon chromosome
Accession NZ_CP088985
Organism Klebsiella pneumoniae strain 53334

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LRZ83_RS04740 Protein ID WP_002916310.1
Coordinates 962678..963088 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LRZ83_RS04745 Protein ID WP_002916312.1
Coordinates 963069..963335 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ83_RS04720 (LRZ83_04720) 958678..960411 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
LRZ83_RS04725 (LRZ83_04725) 960417..961130 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRZ83_RS04730 (LRZ83_04730) 961153..962049 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LRZ83_RS04735 (LRZ83_04735) 962150..962671 + 522 WP_004144730.1 flavodoxin FldB -
LRZ83_RS04740 (LRZ83_04740) 962678..963088 - 411 WP_002916310.1 protein YgfX Toxin
LRZ83_RS04745 (LRZ83_04745) 963069..963335 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LRZ83_RS04750 (LRZ83_04750) 963581..964564 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
LRZ83_RS04755 (LRZ83_04755) 964715..965374 - 660 WP_002916317.1 hemolysin III family protein -
LRZ83_RS04760 (LRZ83_04760) 965538..965849 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LRZ83_RS04765 (LRZ83_04765) 965899..966627 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LRZ83_RS04770 (LRZ83_04770) 966746..968179 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T227219 WP_002916310.1 NZ_CP088985:c963088-962678 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T227219 NZ_CP122801:686240-686554 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT227219 WP_002916312.1 NZ_CP088985:c963335-963069 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227219 NZ_CP122801:686551-686967 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References