Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797429..798086 Replicon chromosome
Accession NZ_CP088982
Organism Klebsiella pneumoniae strain 53357

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LRZ78_RS03960 Protein ID WP_002916310.1
Coordinates 797676..798086 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LRZ78_RS03955 Protein ID WP_002916312.1
Coordinates 797429..797695 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ78_RS03930 (792637) 792637..794070 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LRZ78_RS03935 (794189) 794189..794917 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
LRZ78_RS03940 (794967) 794967..795278 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LRZ78_RS03945 (795442) 795442..796101 + 660 WP_002916317.1 hemolysin III family protein -
LRZ78_RS03950 (796200) 796200..797183 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
LRZ78_RS03955 (797429) 797429..797695 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LRZ78_RS03960 (797676) 797676..798086 + 411 WP_002916310.1 protein YgfX Toxin
LRZ78_RS03965 (798093) 798093..798614 - 522 WP_002916308.1 flavodoxin FldB -
LRZ78_RS03970 (798715) 798715..799611 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LRZ78_RS03975 (799634) 799634..800347 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRZ78_RS03980 (800353) 800353..802086 + 1734 WP_094953199.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T227198 WP_002916310.1 NZ_CP088982:797676-798086 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T227198 NZ_CP122768:2044836-2045087 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT227198 WP_002916312.1 NZ_CP088982:797429-797695 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227198 NZ_CP122768:2045084-2045338 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References