Detailed information of TA system TA227189

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4746716..4747232
• Replicon: chromosome
• Accession: NZ_CP088978
• Organism: Klebsiella pneumoniae strain KP015

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LST75_RS23155
• Protein ID: WP_040188481.1
• Coordinates: 4746716..4747000 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: LST75_RS23160
• Protein ID: WP_002886901.1
• Coordinates: 4746990..4747232 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LST75_RS23130 (LST75_23080)	4742112..4742375	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
LST75_RS23135 (LST75_23085)	4742505..4742678	+	174	WP_002886906.1	hypothetical protein	-
LST75_RS23140 (LST75_23090)	4742681..4743424	+	744	WP_040188479.1	MurR/RpiR family transcriptional regulator	-
LST75_RS23145 (LST75_23095)	4743781..4745919	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
LST75_RS23150 (LST75_23100)	4746248..4746712	+	465	WP_040188480.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LST75_RS23155 (LST75_23105)	4746716..4747000	-	285	WP_040188481.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LST75_RS23160 (LST75_23110)	4746990..4747232	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LST75_RS23165 (LST75_23115)	4747310..4749220	-	1911	WP_004152270.1	PRD domain-containing protein	-
LST75_RS23170 (LST75_23120)	4749243..4750397	-	1155	WP_002886900.1	lactonase family protein	-
LST75_RS23175 (LST75_23125)	4750464..4751204	-	741	WP_040188483.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11086.87 Da
• Isoelectric Point: 10.2562

>T227189 WP_040188481.1 NZ_CP088978:c4747000-4746716 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTSLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T227189 NZ_CP122768:218788-218973 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT227189 WP_002886901.1 NZ_CP088978:c4747232-4746990 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT227189 NZ_CP122768:218990-219400 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGTGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTTGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTATGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0