Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2662546..2664134 Replicon chromosome
Accession NZ_CP088978
Organism Klebsiella pneumoniae strain KP015

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LST75_RS13010 Protein ID WP_040188217.1
Coordinates 2662546..2663868 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LST75_RS13015 Protein ID WP_004176198.1
Coordinates 2663868..2664134 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LST75_RS12995 (LST75_12985) 2657602..2660103 + 2502 WP_040188220.1 fimbria/pilus outer membrane usher protein -
LST75_RS13000 (LST75_12990) 2660091..2661095 + 1005 WP_277738672.1 fimbrial protein -
LST75_RS13005 (LST75_12995) 2661237..2662529 + 1293 WP_277738673.1 glycoside hydrolase family 10 protein -
LST75_RS13010 (LST75_13000) 2662546..2663868 - 1323 WP_040188217.1 type II toxin-antitoxin system HipA family toxin Toxin
LST75_RS13015 (LST75_13005) 2663868..2664134 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LST75_RS13020 (LST75_13010) 2664400..2664726 - 327 WP_004143476.1 hydroxyisourate hydrolase -
LST75_RS13025 (LST75_13015) 2664723..2665223 - 501 WP_040188216.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LST75_RS13030 (LST75_13020) 2665201..2666580 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
LST75_RS13035 (LST75_13025) 2666926..2668080 + 1155 WP_040188215.1 FAD-dependent urate hydroxylase HpxO -
LST75_RS13040 (LST75_13030) 2668061..2668984 - 924 WP_040188213.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2463768..2704678 240910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49097.38 Da        Isoelectric Point: 7.5357

>T227186 WP_040188217.1 NZ_CP088978:c2663868-2662546 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDDAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T227186 NZ_CP122766:c4037-3885 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT227186 WP_004176198.1 NZ_CP088978:c2664134-2663868 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT227186 NZ_CP122766:4087-4149 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References