Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2667340..2668292 Replicon chromosome
Accession NZ_CP088975
Organism Rhodococcus pyridinivorans strain DNHP-S2

Toxin (Protein)


Gene name pezT Uniprot ID H0JT30
Locus tag LSF60_RS12510 Protein ID WP_006552790.1
Coordinates 2667723..2668292 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID H0JT29
Locus tag LSF60_RS12505 Protein ID WP_006552789.1
Coordinates 2667340..2667726 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSF60_RS12485 (LSF60_12485) 2663044..2663976 + 933 WP_231780545.1 TAXI family TRAP transporter solute-binding subunit -
LSF60_RS12490 (LSF60_12490) 2665113..2665613 + 501 WP_231780546.1 hypothetical protein -
LSF60_RS12495 (LSF60_12495) 2665630..2665995 - 366 WP_231780547.1 HNH endonuclease -
LSF60_RS12500 (LSF60_12500) 2666065..2667133 - 1069 Protein_2468 methyltransferase domain-containing protein -
LSF60_RS12505 (LSF60_12505) 2667340..2667726 + 387 WP_006552789.1 hypothetical protein Antitoxin
LSF60_RS12510 (LSF60_12510) 2667723..2668292 + 570 WP_006552790.1 zeta toxin family protein Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-79)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 20552.71 Da        Isoelectric Point: 10.6895

>T227174 WP_006552790.1 NZ_CP088975:2667723-2668292 [Rhodococcus pyridinivorans]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEVGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVTEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWAPAALTGLG

Download         Length: 570 bp

>T227174 NZ_CP122758:c2519494-2519318 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14024.46 Da        Isoelectric Point: 4.5925

>AT227174 WP_006552789.1 NZ_CP088975:2667340-2667726 [Rhodococcus pyridinivorans]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLADGLARTDYAEILAARGVTTVVLDDEGRLVEQRPDGSRQVLDDA

Download         Length: 387 bp

>AT227174 NZ_CP122758:c2519272-2518856 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T7RLW6

Antitoxin

Source ID Structure
AlphaFold DB H0JT29

References