Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 80896..81443 Replicon plasmid pT210003-1
Accession NZ_CP088966
Organism Brucella anthropi strain T210003

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LRL11_RS23635 Protein ID WP_151610665.1
Coordinates 81150..81443 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag LRL11_RS23630 Protein ID WP_151610664.1
Coordinates 80896..81150 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRL11_RS23610 (LRL11_23610) 77025..77900 + 876 WP_113534077.1 ABC transporter substrate-binding protein -
LRL11_RS23615 (LRL11_23615) 78056..78982 + 927 WP_151610661.1 amino acid ABC transporter permease -
LRL11_RS23620 (LRL11_23620) 79006..79758 + 753 WP_192799582.1 amino acid ABC transporter ATP-binding protein -
LRL11_RS23625 (LRL11_23625) 79768..80712 + 945 WP_151610663.1 ornithine cyclodeaminase -
LRL11_RS23630 (LRL11_23630) 80896..81150 + 255 WP_151610664.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LRL11_RS23635 (LRL11_23635) 81150..81443 + 294 WP_151610665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRL11_RS23640 (LRL11_23640) 81613..82326 + 714 WP_231771645.1 IS6 family transposase -
LRL11_RS23645 (LRL11_23645) 82973..83890 - 918 WP_151610692.1 LysR family transcriptional regulator -
LRL11_RS23650 (LRL11_23650) 84016..85053 + 1038 WP_151610686.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
LRL11_RS23655 (LRL11_23655) 85063..86145 + 1083 WP_151610687.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..188867 188867


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(3-70)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11159.93 Da        Isoelectric Point: 6.0740

>T227172 WP_151610665.1 NZ_CP088966:81150-81443 [Brucella anthropi]
MEFKLSVLAEDDIIAIAEQGIAMFGPVQAKRYHAELFNTLDLIAKNPQMARAREEISPPVRVHPFKAHLIIYQIEADGTV
FVIRVRHAFEDWVRDPF

Download         Length: 294 bp

>T227172 NZ_CP122758:2029969-2030072 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9471.75 Da        Isoelectric Point: 9.6920

>AT227172 WP_151610664.1 NZ_CP088966:80896-81150 [Brucella anthropi]
MVTMNVSLPHPMKEWVEAQAKTGRYSNASDYVRDLIRKDQMRSDKIAAMQRFVDEGLQSGPGSRSQDELFAVALANAEKS
LKRN

Download         Length: 255 bp

>AT227172 NZ_CP122758:c2030110-2029839 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References