Detailed information of TA system TA227170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1910960..1912596
• Replicon: chromosome
• Accession: NZ_CP088955
• Organism: Acinetobacter calcoaceticus strain ARu19

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LRO84_RS09110
• Protein ID: WP_231763297.1
• Coordinates: 1910960..1912291 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LRO84_RS09115
• Protein ID: WP_231763298.1
• Coordinates: 1912288..1912596 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRO84_RS09085 (LRO84_09085)	1906914..1907468	+	555	WP_231763292.1	TetR/AcrR family transcriptional regulator	-
LRO84_RS09090 (LRO84_09090)	1907730..1908548	+	819	WP_231763293.1	hypothetical protein	-
LRO84_RS09095 (LRO84_09095)	1908545..1909042	+	498	WP_231763294.1	type II toxin-antitoxin system VapC family toxin	-
LRO84_RS09100 (LRO84_09100)	1909140..1909658	+	519	WP_231763295.1	GNAT family N-acetyltransferase	-
LRO84_RS09105 (LRO84_09105)	1909719..1910714	-	996	WP_231763296.1	putative multidrug efflux protein AdeT1	-
LRO84_RS09110 (LRO84_09110)	1910960..1912291	+	1332	WP_231763297.1	HipA domain-containing protein	Toxin
LRO84_RS09115 (LRO84_09115)	1912288..1912596	+	309	WP_231763298.1	helix-turn-helix transcriptional regulator	Antitoxin
LRO84_RS09120 (LRO84_09120)	1912788..1913024	-	237	WP_004961824.1	VF530 family protein	-
LRO84_RS09125 (LRO84_09125)	1913323..1913637	-	315	WP_231763299.1	hypothetical protein	-
LRO84_RS09130 (LRO84_09130)	1914237..1914527	+	291	WP_231763300.1	hypothetical protein	-
LRO84_RS09135 (LRO84_09135)	1915023..1915556	+	534	WP_003651778.1	fimbrial protein	-
LRO84_RS09140 (LRO84_09140)	1915645..1916376	+	732	WP_004642830.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 50814.76 Da
• Isoelectric Point: 5.2387

>T227170 WP_231763297.1 NZ_CP088955:1910960-1912291 [Acinetobacter calcoaceticus]
MKKLTIQALLDANWLDIAELKLLESKQGSASASELEYKLDYAIQYLDRRDEHACSLSLPVQILVKHESSTWFGFLDDIVP
SGAARRYWVNYLDLQRLTHAEQDSILLEKGGIAPVGNLRIKEALPPVNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQENFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQVLNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCNQQWHRHGLESVYSVLNKSSGSHLNHFEVIEDLCRLLSSIDSDFDASQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLSPIYDFAPMKADPEVVIRSTTWGSPYEEGGEYRWAQITQKLSPWCDPDLSLGILK
ALARNLVGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T227170 NZ_CP122758:1809087-1809338 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11516.44 Da
• Isoelectric Point: 9.9701

>AT227170 WP_231763298.1 NZ_CP088955:1912288-1912596 [Acinetobacter calcoaceticus]
MNVKNQTQDRQQVLIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYAALVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVGKIIKPSE

Nucleotide

• Length: 309 bp

>AT227170 NZ_CP122758:1809335-1809589 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA