Detailed information of TA system TA227169

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 478019..478672
• Replicon: chromosome
• Accession: NZ_CP088955
• Organism: Acinetobacter calcoaceticus strain ARu19

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LRO84_RS02315
• Protein ID: WP_231762488.1
• Coordinates: 478283..478672 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0Q5FRZ3
• Locus tag: LRO84_RS02310
• Protein ID: WP_017388310.1
• Coordinates: 478019..478276 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRO84_RS02290 (LRO84_02290)	473533..474540	+	1008	WP_003653641.1	DNA-directed RNA polymerase subunit alpha	-
LRO84_RS02295 (LRO84_02295)	474559..474936	+	378	WP_002049717.1	50S ribosomal protein L17	-
LRO84_RS02300 (LRO84_02300)	475118..476608	+	1491	WP_231762486.1	NAD(P)/FAD-dependent oxidoreductase	-
LRO84_RS02305 (LRO84_02305)	476657..477829	-	1173	WP_231762487.1	acyl-CoA dehydrogenase family protein	-
LRO84_RS02310 (LRO84_02310)	478019..478276	+	258	WP_017388310.1	succinate dehydrogenase assembly factor 2	Antitoxin
LRO84_RS02315 (LRO84_02315)	478283..478672	+	390	WP_231762488.1	hypothetical protein	Toxin
LRO84_RS02320 (LRO84_02320)	479443..480531	+	1089	WP_231762489.1	hypothetical protein	-
LRO84_RS02325 (LRO84_02325)	480615..481190	+	576	WP_231762490.1	rhombosortase	-
LRO84_RS02330 (LRO84_02330)	481369..483579	+	2211	WP_231762491.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15206.31 Da
• Isoelectric Point: 10.2860

>T227169 WP_231762488.1 NZ_CP088955:478283-478672 [Acinetobacter calcoaceticus]
MIKELNFELKYSRFSIIFQLFIGLSLAILLYQLLSPIGWLIAFILLSISFLFSLRQSRISQIAYLDQKSWSIAYSSQKII
SRVEISKIIDYQLFIVIYLEGAPIKVAIIWFDQLPLQHWKKLKVLQKLH

Nucleotide

• Length: 390 bp

>T227169 NZ_CP122758:987430-987765 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10299.72 Da
• Isoelectric Point: 4.4909

>AT227169 WP_017388310.1 NZ_CP088955:478019-478276 [Acinetobacter calcoaceticus]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADSAEKALFAELVEQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Nucleotide

• Length: 258 bp

>AT227169 NZ_CP122758:987182-987430 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0Q5FRZ3