Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1901916..1903552 Replicon chromosome
Accession NZ_CP088954
Organism Acinetobacter calcoaceticus strain ACa13

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LRO55_RS09000 Protein ID WP_231765219.1
Coordinates 1901916..1903247 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LRO55_RS09005 Protein ID WP_005040627.1
Coordinates 1903244..1903552 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRO55_RS08980 (LRO55_08980) 1897269..1898222 + 954 WP_231765216.1 TauD/TfdA family dioxygenase -
LRO55_RS08985 (LRO55_08985) 1898297..1899397 + 1101 WP_231765298.1 ABC transporter substrate-binding protein -
LRO55_RS08990 (LRO55_08990) 1899687..1899836 + 150 WP_231765217.1 hypothetical protein -
LRO55_RS08995 (LRO55_08995) 1899926..1901698 + 1773 WP_231765218.1 amidohydrolase -
LRO55_RS09000 (LRO55_09000) 1901916..1903247 + 1332 WP_231765219.1 HipA domain-containing protein Toxin
LRO55_RS09005 (LRO55_09005) 1903244..1903552 + 309 WP_005040627.1 helix-turn-helix transcriptional regulator Antitoxin
LRO55_RS09010 (LRO55_09010) 1903651..1905912 - 2262 WP_231765220.1 excinuclease ABC subunit UvrA -
LRO55_RS09015 (LRO55_09015) 1906254..1906490 - 237 WP_231765221.1 VF530 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50899.91 Da        Isoelectric Point: 5.3628

>T227168 WP_231765219.1 NZ_CP088954:1901916-1903247 [Acinetobacter calcoaceticus]
MKKLTIQALLDANWLDIAELKLLESKQGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILVKHESSTWFGFLDDIVP
SGAARRYWVNYLDLQRLTHAEQDSILLEKGGIAPVGNLRIKEAIPPINPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQENFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQVLNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWRNQQWHRHGLESVYSVLNKSSGSHLNHFEVIDDLCKLLTRIDSNFDASQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLSPIYDFAPMKADPEVVTRSMTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLGTLK
SLAINLLGLKQRLVDKGVPKKIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T227168 NZ_CP122758:852167-852574 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11504.43 Da        Isoelectric Point: 10.0639

>AT227168 WP_005040627.1 NZ_CP088954:1903244-1903552 [Acinetobacter calcoaceticus]
MNIKNQTQDRQQVLIDLYKQYLLSEITLGQLLSHLRKNVLGLSQEQYAALVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVGKIIKPSE

Download         Length: 309 bp

>AT227168 NZ_CP122758:851920-852186 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References