Detailed information of TA system TA227167

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 460119..460772
• Replicon: chromosome
• Accession: NZ_CP088954
• Organism: Acinetobacter calcoaceticus strain ACa13

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LRO55_RS02255
• Protein ID: WP_231764543.1
• Coordinates: 460383..460772 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0Q5FRZ3
• Locus tag: LRO55_RS02250
• Protein ID: WP_017388310.1
• Coordinates: 460119..460376 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRO55_RS02230 (LRO55_02230)	455630..456637	+	1008	WP_003653641.1	DNA-directed RNA polymerase subunit alpha	-
LRO55_RS02235 (LRO55_02235)	456656..457033	+	378	WP_002049717.1	50S ribosomal protein L17	-
LRO55_RS02240 (LRO55_02240)	457215..458705	+	1491	WP_231764541.1	NAD(P)/FAD-dependent oxidoreductase	-
LRO55_RS02245 (LRO55_02245)	458757..459929	-	1173	WP_231764542.1	acyl-CoA dehydrogenase family protein	-
LRO55_RS02250 (LRO55_02250)	460119..460376	+	258	WP_017388310.1	succinate dehydrogenase assembly factor 2	Antitoxin
LRO55_RS02255 (LRO55_02255)	460383..460772	+	390	WP_231764543.1	hypothetical protein	Toxin
LRO55_RS02260 (LRO55_02260)	461542..462630	+	1089	WP_003653630.1	hypothetical protein	-
LRO55_RS02265 (LRO55_02265)	462714..463289	+	576	WP_004639503.1	rhombosortase	-
LRO55_RS02270 (LRO55_02270)	463468..465663	+	2196	WP_231764544.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15340.51 Da
• Isoelectric Point: 10.1482

>T227167 WP_231764543.1 NZ_CP088954:460383-460772 [Acinetobacter calcoaceticus]
MIKELNFELKYSRFSIIFQLFIGLSLAILLYQLLSPIWWLIAFILLSISFLFFLRQSQISQIAYLDQKSWSIAYPSQKII
SRVEISKIIDYQLFMVIYLEGAPIKVAIIWFDQLPSVHWKKLKVLQKLH

Nucleotide

• Length: 390 bp

>T227167 NZ_CP122758:744901-745197 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10299.72 Da
• Isoelectric Point: 4.4909

>AT227167 WP_017388310.1 NZ_CP088954:460119-460376 [Acinetobacter calcoaceticus]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADSAEKALFAELVEQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Nucleotide

• Length: 258 bp

>AT227167 NZ_CP122758:745199-745594 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0Q5FRZ3