Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 5180654..5181209 Replicon chromosome
Accession NZ_CP088952
Organism Massilia sp. DM-R-R2A-13

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LSQ66_RS23690 Protein ID WP_231767615.1
Coordinates 5180898..5181209 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LSQ66_RS23685 Protein ID WP_231767614.1
Coordinates 5180654..5180908 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSQ66_RS23660 (LSQ66_23660) 5176604..5177239 + 636 WP_231770188.1 SAM-dependent methyltransferase -
LSQ66_RS23665 (LSQ66_23665) 5177373..5178017 - 645 WP_231767611.1 glutathione S-transferase family protein -
LSQ66_RS23670 (LSQ66_23670) 5178090..5178557 - 468 WP_231767612.1 MarR family transcriptional regulator -
LSQ66_RS23675 (LSQ66_23675) 5178697..5179707 + 1011 WP_269449116.1 alpha/beta hydrolase -
LSQ66_RS23680 (LSQ66_23680) 5179730..5180530 + 801 WP_231767613.1 alpha/beta hydrolase -
LSQ66_RS23685 (LSQ66_23685) 5180654..5180908 + 255 WP_231767614.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LSQ66_RS23690 (LSQ66_23690) 5180898..5181209 + 312 WP_231767615.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LSQ66_RS23695 (LSQ66_23695) 5181384..5182040 + 657 WP_231767616.1 50S ribosomal protein L3 -
LSQ66_RS23700 (LSQ66_23700) 5182044..5182664 + 621 WP_231767617.1 50S ribosomal protein L4 -
LSQ66_RS23705 (LSQ66_23705) 5182661..5182975 + 315 WP_231767618.1 50S ribosomal protein L23 -
LSQ66_RS23710 (LSQ66_23710) 5182975..5183802 + 828 WP_231767619.1 50S ribosomal protein L2 -
LSQ66_RS23715 (LSQ66_23715) 5183812..5184087 + 276 WP_130315950.1 30S ribosomal protein S19 -
LSQ66_RS23720 (LSQ66_23720) 5184084..5184416 + 333 WP_207232949.1 50S ribosomal protein L22 -
LSQ66_RS23725 (LSQ66_23725) 5184426..5185226 + 801 WP_231767620.1 30S ribosomal protein S3 -
LSQ66_RS23730 (LSQ66_23730) 5185229..5185648 + 420 WP_231767621.1 50S ribosomal protein L16 -
LSQ66_RS23735 (LSQ66_23735) 5185661..5185852 + 192 WP_231767622.1 50S ribosomal protein L29 -
LSQ66_RS23740 (LSQ66_23740) 5185849..5186115 + 267 WP_231767623.1 30S ribosomal protein S17 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12082.11 Da        Isoelectric Point: 10.4958

>T227165 WP_231767615.1 NZ_CP088952:5180898-5181209 [Massilia sp. DM-R-R2A-13]
MSYELEFTKSALKEWRDLDPGIREQFKKQLHKRLENPHVPSARLHGSGMGDLYKVKLRDAGYRLVYEVLDQRIVVLVLAV
AKRDKGLAYHLAERRKRAILPER

Download         Length: 312 bp

>T227165 NZ_CP122758:629221-629535 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9134.37 Da        Isoelectric Point: 4.4143

>AT227165 WP_231767614.1 NZ_CP088952:5180654-5180908 [Massilia sp. DM-R-R2A-13]
MAITNSIYAKATVSITELRRNPGQVIEEAGDAAVAILNHNRPAAYLVPASVYEQLLDLLEDAELAELARSRRSEATIKVA
LDEL

Download         Length: 255 bp

>AT227165 NZ_CP122758:629532-629948 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References