Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2292339..2292869 Replicon chromosome
Accession NZ_CP088952
Organism Massilia sp. DM-R-R2A-13

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag LSQ66_RS10165 Protein ID WP_231769660.1
Coordinates 2292612..2292869 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LSQ66_RS10160 Protein ID WP_231769659.1
Coordinates 2292339..2292611 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSQ66_RS10145 (LSQ66_10145) 2288537..2289838 - 1302 WP_231769657.1 dihydrolipoamide acetyltransferase family protein -
LSQ66_RS10150 (LSQ66_10150) 2289840..2290844 - 1005 WP_231770088.1 alpha-ketoacid dehydrogenase subunit beta -
LSQ66_RS10155 (LSQ66_10155) 2290873..2292105 - 1233 WP_231769658.1 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) subunit alpha -
LSQ66_RS10160 (LSQ66_10160) 2292339..2292611 + 273 WP_231769659.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LSQ66_RS10165 (LSQ66_10165) 2292612..2292869 + 258 WP_231769660.1 Txe/YoeB family addiction module toxin Toxin
LSQ66_RS10170 (LSQ66_10170) 2292970..2293908 + 939 WP_269449168.1 4-hydroxyproline epimerase -
LSQ66_RS10175 (LSQ66_10175) 2293905..2294885 - 981 WP_231769661.1 AraC family transcriptional regulator -
LSQ66_RS10180 (LSQ66_10180) 2294823..2295719 + 897 WP_231769662.1 dihydrodipicolinate synthase family protein -
LSQ66_RS10185 (LSQ66_10185) 2295731..2296834 + 1104 WP_231769663.1 FAD-dependent oxidoreductase -
LSQ66_RS10190 (LSQ66_10190) 2296821..2297084 + 264 WP_231769664.1 2Fe-2S iron-sulfur cluster-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10225.60 Da        Isoelectric Point: 8.0123

>T227163 WP_231769660.1 NZ_CP088952:2292612-2292869 [Massilia sp. DM-R-R2A-13]
MRSVKFTDEAWKTYLFWQTQDRKTLKRINDLIEAAQRDPFAGLGKPEALKHSLSGYWSRRIDETNRLVYEVQDDELIIIS
CRYHY

Download         Length: 258 bp

>T227163 NZ_CP122758:c207314-207207 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9727.01 Da        Isoelectric Point: 6.7221

>AT227163 WP_231769659.1 NZ_CP088952:2292339-2292611 [Massilia sp. DM-R-R2A-13]
MRIVNFSDARNSLRAVIDQVVEDADVTVIARRDAPDAVVMSLDHYNSLMETVHLLSSPANAAHLAKSISQARAGQAKQRR
LVGASDAMDP

Download         Length: 273 bp

>AT227163 NZ_CP122758:207362-207428 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References