Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 1006760..1007346 | Replicon | chromosome |
| Accession | NZ_CP088935 | ||
| Organism | Thauera sp. WB-2 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LQF09_RS04635 | Protein ID | WP_270069314.1 |
| Coordinates | 1006760..1007014 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | N6Y054 |
| Locus tag | LQF09_RS04640 | Protein ID | WP_002932339.1 |
| Coordinates | 1007011..1007346 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQF09_RS04590 (LQF09_04590) | 1002010..1002861 | - | 852 | WP_270069306.1 | RNA polymerase sigma factor RpoH | - |
| LQF09_RS04595 (LQF09_04595) | 1002949..1003224 | - | 276 | Protein_909 | PIN domain-containing protein | - |
| LQF09_RS04600 (LQF09_04600) | 1003230..1003640 | - | 411 | WP_270069307.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| LQF09_RS04605 (LQF09_04605) | 1003633..1003881 | - | 249 | WP_270069308.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LQF09_RS04610 (LQF09_04610) | 1004071..1004361 | - | 291 | WP_270069309.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LQF09_RS04615 (LQF09_04615) | 1004358..1004666 | - | 309 | WP_270069310.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LQF09_RS04620 (LQF09_04620) | 1004817..1005047 | + | 231 | WP_270069311.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LQF09_RS04625 (LQF09_04625) | 1005044..1005445 | + | 402 | WP_270069312.1 | type II toxin-antitoxin system VapC family toxin | - |
| LQF09_RS04630 (LQF09_04630) | 1005620..1006633 | + | 1014 | WP_270069313.1 | porin | - |
| LQF09_RS04635 (LQF09_04635) | 1006760..1007014 | + | 255 | WP_270069314.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LQF09_RS04640 (LQF09_04640) | 1007011..1007346 | + | 336 | WP_002932339.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LQF09_RS04645 (LQF09_04645) | 1007512..1008336 | + | 825 | WP_270069315.1 | transposase | - |
| LQF09_RS04650 (LQF09_04650) | 1008400..1008951 | + | 552 | WP_270069316.1 | hypothetical protein | - |
| LQF09_RS04655 (LQF09_04655) | 1009104..1009415 | + | 312 | WP_002932341.1 | hypothetical protein | - |
| LQF09_RS04660 (LQF09_04660) | 1009490..1010041 | + | 552 | WP_270069848.1 | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | - |
| LQF09_RS04665 (LQF09_04665) | 1010336..1011217 | + | 882 | WP_270069317.1 | transglycosylase SLT domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9592.95 Da Isoelectric Point: 10.2881
>T227157 WP_270069314.1 NZ_CP088935:1006760-1007014 [Thauera sp. WB-2]
VKRKHQRTLELIHARPVSANVRWGDIEALFRELGAEISEREGSRVEVFLFGVVRVFHRPHPSPDTDKGAVAAIRKWLEEN
GVQP
VKRKHQRTLELIHARPVSANVRWGDIEALFRELGAEISEREGSRVEVFLFGVVRVFHRPHPSPDTDKGAVAAIRKWLEEN
GVQP
Download Length: 255 bp
>T227157 NZ_CP122727:3567345-3567563 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12044.62 Da Isoelectric Point: 6.4636
>AT227157 WP_002932339.1 NZ_CP088935:1007011-1007346 [Thauera sp. WB-2]
MNTMNIGGYEAVITFDPDIQMFRGEFVGLNGGADFYAADVAGLRREGEVSLRMFLDACERRGIEPRKRFSGKFSLRVDPA
VHEAAVVAAAAHGQSLNQWAAEAIRQAARAG
MNTMNIGGYEAVITFDPDIQMFRGEFVGLNGGADFYAADVAGLRREGEVSLRMFLDACERRGIEPRKRFSGKFSLRVDPA
VHEAAVVAAAAHGQSLNQWAAEAIRQAARAG
Download Length: 336 bp
>AT227157 NZ_CP122727:3566945-3567319 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|