Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/GNAT-DUF1778 |
| Location | 513257..514038 | Replicon | chromosome |
| Accession | NZ_CP088935 | ||
| Organism | Thauera sp. WB-2 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | LQF09_RS02270 | Protein ID | WP_270069068.1 |
| Coordinates | 513532..514038 (+) | Length | 169 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | LQF09_RS02265 | Protein ID | WP_270069067.1 |
| Coordinates | 513257..513535 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQF09_RS02210 (LQF09_02210) | 508665..508910 | + | 246 | WP_002931846.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| LQF09_RS02215 (LQF09_02215) | 508903..509193 | + | 291 | WP_002931847.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LQF09_RS02220 (LQF09_02220) | 509306..509590 | + | 285 | WP_002940158.1 | nucleotidyltransferase family protein | - |
| LQF09_RS02225 (LQF09_02225) | 509643..509852 | + | 210 | WP_270069061.1 | DUF86 domain-containing protein | - |
| LQF09_RS02230 (LQF09_02230) | 510507..510620 | - | 114 | Protein_444 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| LQF09_RS02235 (LQF09_02235) | 511015..511320 | - | 306 | WP_138861463.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LQF09_RS02240 (LQF09_02240) | 511307..511552 | - | 246 | WP_270069062.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| LQF09_RS02245 (LQF09_02245) | 511721..511951 | + | 231 | WP_270069063.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| LQF09_RS02250 (LQF09_02250) | 511958..512359 | + | 402 | WP_270069064.1 | PIN domain-containing protein | - |
| LQF09_RS02255 (LQF09_02255) | 512491..512715 | + | 225 | WP_270069065.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| LQF09_RS02260 (LQF09_02260) | 512730..513191 | + | 462 | WP_270069066.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| LQF09_RS02265 (LQF09_02265) | 513257..513535 | + | 279 | WP_270069067.1 | DUF1778 domain-containing protein | Antitoxin |
| LQF09_RS02270 (LQF09_02270) | 513532..514038 | + | 507 | WP_270069068.1 | GNAT family N-acetyltransferase | Toxin |
| LQF09_RS02275 (LQF09_02275) | 514083..514415 | - | 333 | WP_002945665.1 | type II toxin-antitoxin system VapC family toxin | - |
| LQF09_RS02280 (LQF09_02280) | 514482..514712 | + | 231 | WP_270069063.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| LQF09_RS02285 (LQF09_02285) | 514719..515120 | + | 402 | WP_270069064.1 | PIN domain-containing protein | - |
| LQF09_RS02290 (LQF09_02290) | 515269..515493 | + | 225 | WP_270069065.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| LQF09_RS02295 (LQF09_02295) | 515490..515918 | + | 429 | WP_270069069.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| LQF09_RS02300 (LQF09_02300) | 515952..516227 | - | 276 | WP_270069070.1 | twitching motility protein PilT | - |
| LQF09_RS02305 (LQF09_02305) | 516238..516849 | - | 612 | WP_270069071.1 | glutathione S-transferase | - |
| LQF09_RS02310 (LQF09_02310) | 517047..517637 | + | 591 | WP_037983318.1 | nucleotidyltransferase domain-containing protein | - |
| LQF09_RS02315 (LQF09_02315) | 517734..518390 | - | 657 | WP_002931860.1 | alpha/beta fold hydrolase | - |
| LQF09_RS02320 (LQF09_02320) | 518387..518710 | - | 324 | WP_270069072.1 | ferredoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 494023..517637 | 23614 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 169 a.a. Molecular weight: 18304.08 Da Isoelectric Point: 8.1444
>T227154 WP_270069068.1 NZ_CP088935:513532-514038 [Thauera sp. WB-2]
MSAGYEPVRKLSPADSTEAFDCGQPALNQFLQRHALVSQKANSAQTYVCCLSSKVVGFYSLAVGSVDSGEAPARVRKSLA
RHPVPVMILARLAVDRDHQGVGLGKALLKDALLRTAQAAEIAGIRCVLVHAKDEAARQWYASWEFEPSPTDPYHLFLMLK
DLRALLAE
MSAGYEPVRKLSPADSTEAFDCGQPALNQFLQRHALVSQKANSAQTYVCCLSSKVVGFYSLAVGSVDSGEAPARVRKSLA
RHPVPVMILARLAVDRDHQGVGLGKALLKDALLRTAQAAEIAGIRCVLVHAKDEAARQWYASWEFEPSPTDPYHLFLMLK
DLRALLAE
Download Length: 507 bp
>T227154 NZ_CP122727:2690936-2691043 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10225.67 Da Isoelectric Point: 9.2511
>AT227154 WP_270069067.1 NZ_CP088935:513257-513535 [Thauera sp. WB-2]
VSTPSLSKTERIDVRASSAVKQLLQEAARSCHKNVSEFLLEAGIIAADQALADRRRFGLDDERWQAFQQALDRPVQAKPR
LKKLLGEPGVLD
VSTPSLSKTERIDVRASSAVKQLLQEAARSCHKNVSEFLLEAGIIAADQALADRRRFGLDDERWQAFQQALDRPVQAKPR
LKKLLGEPGVLD
Download Length: 279 bp
>AT227154 NZ_CP122727:c2690889-2690823 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|