Detailed information of TA system TA227153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 511015..511552
• Replicon: chromosome
• Accession: NZ_CP088935
• Organism: Thauera sp. WB-2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LQF09_RS02235
• Protein ID: WP_138861463.1
• Coordinates: 511015..511320 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LQF09_RS02240
• Protein ID: WP_270069062.1
• Coordinates: 511307..511552 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQF09_RS02195 (LQF09_02195)	506617..506979	-	363	WP_002931843.1	divalent-cation tolerance protein CutA	-
LQF09_RS02200 (LQF09_02200)	507206..507784	-	579	WP_002940167.1	histidine phosphatase family protein	-
LQF09_RS02205 (LQF09_02205)	507971..508516	+	546	WP_232431615.1	hemerythrin domain-containing protein	-
LQF09_RS02210 (LQF09_02210)	508665..508910	+	246	WP_002931846.1	type II toxin-antitoxin system ParD family antitoxin	-
LQF09_RS02215 (LQF09_02215)	508903..509193	+	291	WP_002931847.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LQF09_RS02220 (LQF09_02220)	509306..509590	+	285	WP_002940158.1	nucleotidyltransferase family protein	-
LQF09_RS02225 (LQF09_02225)	509643..509852	+	210	WP_270069061.1	DUF86 domain-containing protein	-
LQF09_RS02230 (LQF09_02230)	510507..510620	-	114	Protein_444	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
LQF09_RS02235 (LQF09_02235)	511015..511320	-	306	WP_138861463.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LQF09_RS02240 (LQF09_02240)	511307..511552	-	246	WP_270069062.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LQF09_RS02245 (LQF09_02245)	511721..511951	+	231	WP_270069063.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
LQF09_RS02250 (LQF09_02250)	511958..512359	+	402	WP_270069064.1	PIN domain-containing protein	-
LQF09_RS02255 (LQF09_02255)	512491..512715	+	225	WP_270069065.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
LQF09_RS02260 (LQF09_02260)	512730..513191	+	462	WP_270069066.1	putative toxin-antitoxin system toxin component, PIN family	-
LQF09_RS02265 (LQF09_02265)	513257..513535	+	279	WP_270069067.1	DUF1778 domain-containing protein	-
LQF09_RS02270 (LQF09_02270)	513532..514038	+	507	WP_270069068.1	GNAT family N-acetyltransferase	-
LQF09_RS02275 (LQF09_02275)	514083..514415	-	333	WP_002945665.1	type II toxin-antitoxin system VapC family toxin	-
LQF09_RS02280 (LQF09_02280)	514482..514712	+	231	WP_270069063.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
LQF09_RS02285 (LQF09_02285)	514719..515120	+	402	WP_270069064.1	PIN domain-containing protein	-
LQF09_RS02290 (LQF09_02290)	515269..515493	+	225	WP_270069065.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
LQF09_RS02295 (LQF09_02295)	515490..515918	+	429	WP_270069069.1	putative toxin-antitoxin system toxin component, PIN family	-
LQF09_RS02300 (LQF09_02300)	515952..516227	-	276	WP_270069070.1	twitching motility protein PilT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	494023..517637	23614

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-70)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11607.53 Da
• Isoelectric Point: 10.2668

>T227153 WP_138861463.1 NZ_CP088935:c511320-511015 [Thauera sp. WB-2]
MTTCKLRFHTLALAEWQKLDGSVRTQFKKKLEERLITPRVPAAALSGMADCYKIKLRAAGYRLVYRVDDGEVWVTVISIG
LRERLQAYTRAQARLDDPPRD

Nucleotide

• Length: 306 bp

>T227153 NZ_CP122727:2365725-2367047 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9119.25 Da
• Isoelectric Point: 4.4193

>AT227153 WP_270069062.1 NZ_CP088935:c511552-511307 [Thauera sp. WB-2]
MQTIMADLTVSVTELKRNFASILAQADDQPVAVLNHNRPEAYLLSAAHYQRLLTHLEDLEDAARVRERSEGPFVEVSLDD
L

Nucleotide

• Length: 246 bp

>AT227153 NZ_CP122727:2365459-2365725 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA